Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease
Neutrophils have been found to play an important role in the pathogenesis of inflammatory bowel disease (IBD), and anti-TNF-α mAb (i.e., infliximab) therapy is demonstrated to be effective in the induction of clinical remission and mucosal healing in these patients. However, how anti-TNF-α mAb regul...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/3021863 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566804079181824 |
|---|---|
| author | Cui Zhang Weigang Shu Guangxi Zhou Jian Lin Feifei Chu Huili Wu Zhanju Liu |
| author_facet | Cui Zhang Weigang Shu Guangxi Zhou Jian Lin Feifei Chu Huili Wu Zhanju Liu |
| author_sort | Cui Zhang |
| collection | DOAJ |
| description | Neutrophils have been found to play an important role in the pathogenesis of inflammatory bowel disease (IBD), and anti-TNF-α mAb (i.e., infliximab) therapy is demonstrated to be effective in the induction of clinical remission and mucosal healing in these patients. However, how anti-TNF-α mAb regulates the functions of neutrophils is still unknown. Herein, we found that anti-TNF-α therapy significantly downregulated infiltration of neutrophils in inflamed mucosa of IBD patients. Importantly, anti-TNF-α mAb could inhibit neutrophils to produce proinflammatory mediators, such as ROS, calprotectin, IL-8, IL-6, and TNF-α. These data indicate that TNF-α plays a critical role in the induction of mucosal inflammatory response, and that blockade of TNF-α modulates intestinal homeostasis through balancing immune responses of neutrophils. |
| format | Article |
| id | doaj-art-2452de80b6dd4ae8970d0fe6c16c1f2a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2452de80b6dd4ae8970d0fe6c16c1f2a2025-02-03T01:02:59ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/30218633021863Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel DiseaseCui Zhang0Weigang Shu1Guangxi Zhou2Jian Lin3Feifei Chu4Huili Wu5Zhanju Liu6Department of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province 450007, ChinaDepartment of Gastroenterology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan Province 450007, ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, ChinaNeutrophils have been found to play an important role in the pathogenesis of inflammatory bowel disease (IBD), and anti-TNF-α mAb (i.e., infliximab) therapy is demonstrated to be effective in the induction of clinical remission and mucosal healing in these patients. However, how anti-TNF-α mAb regulates the functions of neutrophils is still unknown. Herein, we found that anti-TNF-α therapy significantly downregulated infiltration of neutrophils in inflamed mucosa of IBD patients. Importantly, anti-TNF-α mAb could inhibit neutrophils to produce proinflammatory mediators, such as ROS, calprotectin, IL-8, IL-6, and TNF-α. These data indicate that TNF-α plays a critical role in the induction of mucosal inflammatory response, and that blockade of TNF-α modulates intestinal homeostasis through balancing immune responses of neutrophils.http://dx.doi.org/10.1155/2018/3021863 |
| spellingShingle | Cui Zhang Weigang Shu Guangxi Zhou Jian Lin Feifei Chu Huili Wu Zhanju Liu Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease Mediators of Inflammation |
| title | Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease |
| title_full | Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease |
| title_fullStr | Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease |
| title_full_unstemmed | Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease |
| title_short | Anti-TNF-α Therapy Suppresses Proinflammatory Activities of Mucosal Neutrophils in Inflammatory Bowel Disease |
| title_sort | anti tnf α therapy suppresses proinflammatory activities of mucosal neutrophils in inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2018/3021863 |
| work_keys_str_mv | AT cuizhang antitnfatherapysuppressesproinflammatoryactivitiesofmucosalneutrophilsininflammatoryboweldisease AT weigangshu antitnfatherapysuppressesproinflammatoryactivitiesofmucosalneutrophilsininflammatoryboweldisease AT guangxizhou antitnfatherapysuppressesproinflammatoryactivitiesofmucosalneutrophilsininflammatoryboweldisease AT jianlin antitnfatherapysuppressesproinflammatoryactivitiesofmucosalneutrophilsininflammatoryboweldisease AT feifeichu antitnfatherapysuppressesproinflammatoryactivitiesofmucosalneutrophilsininflammatoryboweldisease AT huiliwu antitnfatherapysuppressesproinflammatoryactivitiesofmucosalneutrophilsininflammatoryboweldisease AT zhanjuliu antitnfatherapysuppressesproinflammatoryactivitiesofmucosalneutrophilsininflammatoryboweldisease |