The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach
Breast cancer is one of the leading causes of mortality among women worldwide, prompting the exploration of alternative, natural therapies. This study examines the anti-breast cancer potential of traditional herbal plants used by the Dayak tribe, particularly Kleinhovia hospita Linn. Through in sili...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/04/bioconf_icnf2024_01006.pdf |
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| author | Kellik Setiawan Volta Affan Ali Murtadlo Ahmad Nur Muhammad Ansori Arif Dhea Kharisma Viol Dayu Rahma Turista Dora |
| author_facet | Kellik Setiawan Volta Affan Ali Murtadlo Ahmad Nur Muhammad Ansori Arif Dhea Kharisma Viol Dayu Rahma Turista Dora |
| author_sort | Kellik Setiawan Volta |
| collection | DOAJ |
| description | Breast cancer is one of the leading causes of mortality among women worldwide, prompting the exploration of alternative, natural therapies. This study examines the anti-breast cancer potential of traditional herbal plants used by the Dayak tribe, particularly Kleinhovia hospita Linn. Through in silico approaches, the study investigates the cytotoxic effects and binding affinities of key compounds, such as Scopoletin, Quercetin, and Eleutherol, with breast cancer-related proteins. Molecular docking analysis demonstrated that Quercetin and Eleutherol exhibit high binding affinities (−9 and −8 kcal/mol, respectively) with target proteins, indicating significant potential for inhibiting cancer cell proliferation by targeting proteins like EGFR, JNK, and NUDT5. The drug-likeness analysis confirmed that Quercetin and Eleutherol meet criteria for further therapeutic exploration. These findings suggest that compounds from Dayak tribal plants could be viable anti-cancer agents, providing a scientific foundation for developing culturally relevant and effective treatments for breast cancer. Further research is recommended to isolate and evaluate the bioactive compounds in preclinical and clinical settings. This work supports the potential of traditional Dayak herbal medicine as a natural therapeutic strategy against breast cancer. |
| format | Article |
| id | doaj-art-243e64a06a6949ac9c53ea46e91d42b3 |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-243e64a06a6949ac9c53ea46e91d42b32025-02-05T10:42:59ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011530100610.1051/bioconf/202515301006bioconf_icnf2024_01006The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approachKellik Setiawan Volta0Affan Ali Murtadlo Ahmad1Nur Muhammad Ansori Arif2Dhea Kharisma Viol3Dayu Rahma Turista Dora4Biology Education Study Program, Faculty of Teacher Training and Education, Mulawarman UniversityGenerasi Biologi Indonesia FoundationDepartment of Biology, Faculty of Science and Technology, Universitas AirlanggaDivision of Research and Development, CV Jalan TengahBiology Education Study Program, Faculty of Teacher Training and Education, Mulawarman UniversityBreast cancer is one of the leading causes of mortality among women worldwide, prompting the exploration of alternative, natural therapies. This study examines the anti-breast cancer potential of traditional herbal plants used by the Dayak tribe, particularly Kleinhovia hospita Linn. Through in silico approaches, the study investigates the cytotoxic effects and binding affinities of key compounds, such as Scopoletin, Quercetin, and Eleutherol, with breast cancer-related proteins. Molecular docking analysis demonstrated that Quercetin and Eleutherol exhibit high binding affinities (−9 and −8 kcal/mol, respectively) with target proteins, indicating significant potential for inhibiting cancer cell proliferation by targeting proteins like EGFR, JNK, and NUDT5. The drug-likeness analysis confirmed that Quercetin and Eleutherol meet criteria for further therapeutic exploration. These findings suggest that compounds from Dayak tribal plants could be viable anti-cancer agents, providing a scientific foundation for developing culturally relevant and effective treatments for breast cancer. Further research is recommended to isolate and evaluate the bioactive compounds in preclinical and clinical settings. This work supports the potential of traditional Dayak herbal medicine as a natural therapeutic strategy against breast cancer.https://www.bio-conferences.org/articles/bioconf/pdf/2025/04/bioconf_icnf2024_01006.pdf |
| spellingShingle | Kellik Setiawan Volta Affan Ali Murtadlo Ahmad Nur Muhammad Ansori Arif Dhea Kharisma Viol Dayu Rahma Turista Dora The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach BIO Web of Conferences |
| title | The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach |
| title_full | The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach |
| title_fullStr | The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach |
| title_full_unstemmed | The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach |
| title_short | The potential of Dayak tribal herbal leaves as an anti-breast cancer agent: In silico approach |
| title_sort | potential of dayak tribal herbal leaves as an anti breast cancer agent in silico approach |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/04/bioconf_icnf2024_01006.pdf |
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