Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based cross-sectional study
Background: The correlation between plasma C-reactive protein (CRP) and aggression in schizophrenia has recently become an area of interest. As an acute phase reactant, neuro-immuno-modulatory and neurohumoral functions of CRP might have a role in understanding causation of aggression in disease and...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-06-01
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| Series: | Indian Journal of Psychiatry |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_427_22 |
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| _version_ | 1832591216387031040 |
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| author | Aru Shikha Singh Lakshimi Borgohain Bhupindar Singh |
| author_facet | Aru Shikha Singh Lakshimi Borgohain Bhupindar Singh |
| author_sort | Aru Shikha Singh |
| collection | DOAJ |
| description | Background:
The correlation between plasma C-reactive protein (CRP) and aggression in schizophrenia has recently become an area of interest. As an acute phase reactant, neuro-immuno-modulatory and neurohumoral functions of CRP might have a role in understanding causation of aggression in disease and this may have implications in therapeutic intervention.
Aims:
To assess aggression and plasma CRP in patients with schizophrenia and to compare aggression in patients with normal and elevated CRP.
Methods and Material:
A hospital-based cross-sectional study was carried out over a period of one year (2019-2020). Patients of schizophrenia as per International Classification of Diseases 10 were selected. Modified Overt Aggression Scale was applied, and plasma CRP levels were estimated in the selected patients.
Statistical Analysis:
Mean aggression scores were compared in patients with normal and elevated CRP. And aggression scores were correlated with plasma CRP levels.
Results:
Mean aggression score (22.93 ± 2.80) was significantly (P < .001) higher in patients with elevated CRP. There is a positive correlation (r = 0.855, P < .001) between aggression and plasma CRP.
Conclusion:
Patients with elevated CRP were more aggressive compared to the patients with normal CRP. |
| format | Article |
| id | doaj-art-243ad8751ca44ee3bbca783a2bc4e1e3 |
| institution | Kabale University |
| issn | 0019-5545 1998-3794 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Psychiatry |
| spelling | doaj-art-243ad8751ca44ee3bbca783a2bc4e1e32025-01-22T14:56:24ZengWolters Kluwer Medknow PublicationsIndian Journal of Psychiatry0019-55451998-37942023-06-0165666767010.4103/indianjpsychiatry.indianjpsychiatry_427_22Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based cross-sectional studyAru Shikha SinghLakshimi BorgohainBhupindar SinghBackground: The correlation between plasma C-reactive protein (CRP) and aggression in schizophrenia has recently become an area of interest. As an acute phase reactant, neuro-immuno-modulatory and neurohumoral functions of CRP might have a role in understanding causation of aggression in disease and this may have implications in therapeutic intervention. Aims: To assess aggression and plasma CRP in patients with schizophrenia and to compare aggression in patients with normal and elevated CRP. Methods and Material: A hospital-based cross-sectional study was carried out over a period of one year (2019-2020). Patients of schizophrenia as per International Classification of Diseases 10 were selected. Modified Overt Aggression Scale was applied, and plasma CRP levels were estimated in the selected patients. Statistical Analysis: Mean aggression scores were compared in patients with normal and elevated CRP. And aggression scores were correlated with plasma CRP levels. Results: Mean aggression score (22.93 ± 2.80) was significantly (P < .001) higher in patients with elevated CRP. There is a positive correlation (r = 0.855, P < .001) between aggression and plasma CRP. Conclusion: Patients with elevated CRP were more aggressive compared to the patients with normal CRP.https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_427_22acute phase reactantsinflammatory markerneuro-immuno-modulatorpsychosis |
| spellingShingle | Aru Shikha Singh Lakshimi Borgohain Bhupindar Singh Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based cross-sectional study Indian Journal of Psychiatry acute phase reactants inflammatory marker neuro-immuno-modulator psychosis |
| title | Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based cross-sectional study |
| title_full | Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based cross-sectional study |
| title_fullStr | Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based cross-sectional study |
| title_full_unstemmed | Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based cross-sectional study |
| title_short | Aggression and its correlation with plasma C-reactive protein levels in patients with schizophrenia: A hospital based cross-sectional study |
| title_sort | aggression and its correlation with plasma c reactive protein levels in patients with schizophrenia a hospital based cross sectional study |
| topic | acute phase reactants inflammatory marker neuro-immuno-modulator psychosis |
| url | https://journals.lww.com/10.4103/indianjpsychiatry.indianjpsychiatry_427_22 |
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