Synthesis of Tumbleweed-like MoSe<sub>2</sub> Nanostructures for Ultrasensitive Electrochemical Detection of Uric Acid
Uric acid (UA), the final metabolic product of purines, plays a crucial role in human health monitoring. The UA concentration in biological fluids serves as a diagnostic marker for various disorders, particularly kidney diseases, and represents a potential therapeutic target. Given the growing empha...
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MDPI AG
2025-03-01
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| author | Peizheng Shi Ningbin Zhao Zhuang Sun Kaiqiang Sun Wubo Chu Hsu-Sheng Tsai Lidong Wu Tao Cai Yuezhong Wang Nan Jiang Chen Ye Li Fu Lixin Xu Cheng-Te Lin |
| author_facet | Peizheng Shi Ningbin Zhao Zhuang Sun Kaiqiang Sun Wubo Chu Hsu-Sheng Tsai Lidong Wu Tao Cai Yuezhong Wang Nan Jiang Chen Ye Li Fu Lixin Xu Cheng-Te Lin |
| author_sort | Peizheng Shi |
| collection | DOAJ |
| description | Uric acid (UA), the final metabolic product of purines, plays a crucial role in human health monitoring. The UA concentration in biological fluids serves as a diagnostic marker for various disorders, particularly kidney diseases, and represents a potential therapeutic target. Given the growing emphasis on preventive healthcare, developing methods for real-time UA detection has become increasingly significant. Here, we demonstrate the synthesis of novel tumbleweed-like molybdenum diselenide (MoSe<sub>2</sub>) nanostructures through a single-step hydrothermal process. The synthesized MoSe<sub>2</sub> was subsequently hybridized with reduced graphene oxide (rGO) to construct electrodes for UA sensing. Differential pulse voltammetry (DPV) measurements revealed that the MoSe<sub>2</sub>/rGO-modified glassy carbon electrode (GCE) exhibited excellent UA detection capabilities under optimized conditions. The sensor demonstrated a remarkably low limit of detection (LOD) of 28.4 nM and maintained linearity across a wide concentration range (40 nM to 200 μM). Notably, the sensor showed high selectivity for UA detection even in the presence of common interfering species, including citric acid (CA), dopamine (DA), ascorbic acid (AA), cysteine (Cys), glucose (Glu), oxalic acid (OA), sodium ions (Na<sup>+</sup>), and potassium ions (K<sup>+</sup>). The developed sensor displayed outstanding selectivity, stability, and reproducibility characteristics. This synthetic approach offers promising opportunities for developing MoSe<sub>2</sub>-based electrochemical sensing platforms suitable for diverse bioanalytical applications. |
| format | Article |
| id | doaj-art-242b5c06a36a42a496bbba1c91a919c7 |
| institution | OA Journals |
| issn | 2227-9040 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj-art-242b5c06a36a42a496bbba1c91a919c72025-08-20T02:11:09ZengMDPI AGChemosensors2227-90402025-03-011338110.3390/chemosensors13030081Synthesis of Tumbleweed-like MoSe<sub>2</sub> Nanostructures for Ultrasensitive Electrochemical Detection of Uric AcidPeizheng Shi0Ningbin Zhao1Zhuang Sun2Kaiqiang Sun3Wubo Chu4Hsu-Sheng Tsai5Lidong Wu6Tao Cai7Yuezhong Wang8Nan Jiang9Chen Ye10Li Fu11Lixin Xu12Cheng-Te Lin13College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, ChinaQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaSchool of Physics, Harbin Institute of Technology, Harbin 150001, ChinaKey Laboratory of Control of Quality and Safety for Aquatic Products, Chinese Academy of Fishery Sciences, Beijing 100141, ChinaState Key Laboratory of Advanced Marine Materials, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaState Key Laboratory of Advanced Marine Materials, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaState Key Laboratory of Advanced Marine Materials, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaQianwan Institute, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaCollege of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, ChinaCollege of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, ChinaState Key Laboratory of Advanced Marine Materials, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, ChinaUric acid (UA), the final metabolic product of purines, plays a crucial role in human health monitoring. The UA concentration in biological fluids serves as a diagnostic marker for various disorders, particularly kidney diseases, and represents a potential therapeutic target. Given the growing emphasis on preventive healthcare, developing methods for real-time UA detection has become increasingly significant. Here, we demonstrate the synthesis of novel tumbleweed-like molybdenum diselenide (MoSe<sub>2</sub>) nanostructures through a single-step hydrothermal process. The synthesized MoSe<sub>2</sub> was subsequently hybridized with reduced graphene oxide (rGO) to construct electrodes for UA sensing. Differential pulse voltammetry (DPV) measurements revealed that the MoSe<sub>2</sub>/rGO-modified glassy carbon electrode (GCE) exhibited excellent UA detection capabilities under optimized conditions. The sensor demonstrated a remarkably low limit of detection (LOD) of 28.4 nM and maintained linearity across a wide concentration range (40 nM to 200 μM). Notably, the sensor showed high selectivity for UA detection even in the presence of common interfering species, including citric acid (CA), dopamine (DA), ascorbic acid (AA), cysteine (Cys), glucose (Glu), oxalic acid (OA), sodium ions (Na<sup>+</sup>), and potassium ions (K<sup>+</sup>). The developed sensor displayed outstanding selectivity, stability, and reproducibility characteristics. This synthetic approach offers promising opportunities for developing MoSe<sub>2</sub>-based electrochemical sensing platforms suitable for diverse bioanalytical applications.https://www.mdpi.com/2227-9040/13/3/81electrochemical biosensorsuric acidhydrothermal methodtumbleweed-like MoSe<sub>2</sub> |
| spellingShingle | Peizheng Shi Ningbin Zhao Zhuang Sun Kaiqiang Sun Wubo Chu Hsu-Sheng Tsai Lidong Wu Tao Cai Yuezhong Wang Nan Jiang Chen Ye Li Fu Lixin Xu Cheng-Te Lin Synthesis of Tumbleweed-like MoSe<sub>2</sub> Nanostructures for Ultrasensitive Electrochemical Detection of Uric Acid Chemosensors electrochemical biosensors uric acid hydrothermal method tumbleweed-like MoSe<sub>2</sub> |
| title | Synthesis of Tumbleweed-like MoSe<sub>2</sub> Nanostructures for Ultrasensitive Electrochemical Detection of Uric Acid |
| title_full | Synthesis of Tumbleweed-like MoSe<sub>2</sub> Nanostructures for Ultrasensitive Electrochemical Detection of Uric Acid |
| title_fullStr | Synthesis of Tumbleweed-like MoSe<sub>2</sub> Nanostructures for Ultrasensitive Electrochemical Detection of Uric Acid |
| title_full_unstemmed | Synthesis of Tumbleweed-like MoSe<sub>2</sub> Nanostructures for Ultrasensitive Electrochemical Detection of Uric Acid |
| title_short | Synthesis of Tumbleweed-like MoSe<sub>2</sub> Nanostructures for Ultrasensitive Electrochemical Detection of Uric Acid |
| title_sort | synthesis of tumbleweed like mose sub 2 sub nanostructures for ultrasensitive electrochemical detection of uric acid |
| topic | electrochemical biosensors uric acid hydrothermal method tumbleweed-like MoSe<sub>2</sub> |
| url | https://www.mdpi.com/2227-9040/13/3/81 |
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