The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity
Introduction. Iron deficiency (ID) is the most common nutritional deficiency found in pediatric practice. A higher prevalence of ID may be found in children with obesity. Obesity is a chronic low-grade inflammatory condition. It is postulated that inflammation increases hepcidin, a regulator of iron...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2021/9944035 |
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| author | Ekkarit Panichsillaphakit Orapa Suteerojntrakool Chitsanu Pancharoen Issarang Nuchprayoon Sirinuch Chomtho |
| author_facet | Ekkarit Panichsillaphakit Orapa Suteerojntrakool Chitsanu Pancharoen Issarang Nuchprayoon Sirinuch Chomtho |
| author_sort | Ekkarit Panichsillaphakit |
| collection | DOAJ |
| description | Introduction. Iron deficiency (ID) is the most common nutritional deficiency found in pediatric practice. A higher prevalence of ID may be found in children with obesity. Obesity is a chronic low-grade inflammatory condition. It is postulated that inflammation increases hepcidin, a regulator of iron homeostasis. The aim of this study was to investigate the associations between iron status, hepcidin, and BMI-standard deviation score (BMI-SDS) in children with and without obesity. Methods. A cross-sectional study of Thai children with obesity (5 to 15 years old) versus age- and sex-matched, nonobese controls was conducted. A total of 63 children with obesity and 27 controls were enrolled. Complete blood count, serum iron, ferritin, transferrin saturation, and total iron binding capacity were analyzed. Serum hepcidin-25 was assayed using a hepcidin ELISA Kit (Human Hepc25). Results. There were 63 children with obesity, the median age (IQR) being 10 (9–13) years, and 27 controls. The median (IQR) BMI-SDS of the obese group was 2.3 (2.0–2.6) vs. −0.5 ((−1.3)−0.4) of the control group. ID was diagnosed in 27 children in the obese group (42.9%); 4 of the children with obesity and ID had anemia. Serum hepcidin-25 levels of the children with ID vs. without ID in the obese group were not significantly different (median (IQR) 25 (12.9–49.2) and 26.4 (12.6–43.6), respectively) but both of them were significantly higher than controls (19.7 (8.3–25.5) ng/ml, p = 0.04). BMI-SDS was positively correlated with hepcidin-25 (r = 0.28, p = 0.001). Conclusion. Prevalence of iron deficiency in Thai children with obesity and serum hepcidin-25 was higher than controls. Further study in a larger population, preferably with interventions such as weight loss program, is warranted to clarify this association. |
| format | Article |
| id | doaj-art-242a9fe775524892bc795349a20fd61a |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-242a9fe775524892bc795349a20fd61a2025-02-03T01:13:07ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322021-01-01202110.1155/2021/99440359944035The Association between Hepcidin and Iron Status in Children and Adolescents with ObesityEkkarit Panichsillaphakit0Orapa Suteerojntrakool1Chitsanu Pancharoen2Issarang Nuchprayoon3Sirinuch Chomtho4Division of Nutrition, Department of Pediatrics, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, ThailandAmbulatory Division, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandInfectious Division, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandPalliative Care Unit, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandPediatric Nutrition Research Unit, Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, ThailandIntroduction. Iron deficiency (ID) is the most common nutritional deficiency found in pediatric practice. A higher prevalence of ID may be found in children with obesity. Obesity is a chronic low-grade inflammatory condition. It is postulated that inflammation increases hepcidin, a regulator of iron homeostasis. The aim of this study was to investigate the associations between iron status, hepcidin, and BMI-standard deviation score (BMI-SDS) in children with and without obesity. Methods. A cross-sectional study of Thai children with obesity (5 to 15 years old) versus age- and sex-matched, nonobese controls was conducted. A total of 63 children with obesity and 27 controls were enrolled. Complete blood count, serum iron, ferritin, transferrin saturation, and total iron binding capacity were analyzed. Serum hepcidin-25 was assayed using a hepcidin ELISA Kit (Human Hepc25). Results. There were 63 children with obesity, the median age (IQR) being 10 (9–13) years, and 27 controls. The median (IQR) BMI-SDS of the obese group was 2.3 (2.0–2.6) vs. −0.5 ((−1.3)−0.4) of the control group. ID was diagnosed in 27 children in the obese group (42.9%); 4 of the children with obesity and ID had anemia. Serum hepcidin-25 levels of the children with ID vs. without ID in the obese group were not significantly different (median (IQR) 25 (12.9–49.2) and 26.4 (12.6–43.6), respectively) but both of them were significantly higher than controls (19.7 (8.3–25.5) ng/ml, p = 0.04). BMI-SDS was positively correlated with hepcidin-25 (r = 0.28, p = 0.001). Conclusion. Prevalence of iron deficiency in Thai children with obesity and serum hepcidin-25 was higher than controls. Further study in a larger population, preferably with interventions such as weight loss program, is warranted to clarify this association.http://dx.doi.org/10.1155/2021/9944035 |
| spellingShingle | Ekkarit Panichsillaphakit Orapa Suteerojntrakool Chitsanu Pancharoen Issarang Nuchprayoon Sirinuch Chomtho The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity Journal of Nutrition and Metabolism |
| title | The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity |
| title_full | The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity |
| title_fullStr | The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity |
| title_full_unstemmed | The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity |
| title_short | The Association between Hepcidin and Iron Status in Children and Adolescents with Obesity |
| title_sort | association between hepcidin and iron status in children and adolescents with obesity |
| url | http://dx.doi.org/10.1155/2021/9944035 |
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