The impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstruction
Abstract Background To determine the impact of Human Papillomavirus (HPV) status on speech, swallowing, and quality of life (QOL) outcomes after surgical treatment of oropharyngeal cancer (OPSCC). Methods A retrospective review of a prospectively collected database of all patients with OPSCC diagnos...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-09-01
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| Series: | Journal of Otolaryngology - Head and Neck Surgery |
| Online Access: | http://link.springer.com/article/10.1186/s40463-018-0301-z |
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| author | Hani Z. Marzouki Vincent L. Biron Peter T. Dziegielewski Andrew Ma Jason Vaz Gabriela Constantinescu Jeffrey Harris Daniel O’Connell Hadi Seikaly |
| author_facet | Hani Z. Marzouki Vincent L. Biron Peter T. Dziegielewski Andrew Ma Jason Vaz Gabriela Constantinescu Jeffrey Harris Daniel O’Connell Hadi Seikaly |
| author_sort | Hani Z. Marzouki |
| collection | DOAJ |
| description | Abstract Background To determine the impact of Human Papillomavirus (HPV) status on speech, swallowing, and quality of life (QOL) outcomes after surgical treatment of oropharyngeal cancer (OPSCC). Methods A retrospective review of a prospectively collected database of all patients with OPSCC diagnosed and treated from 1998 to 2009. Speech, swallowing, and quality of life data were gathered at 3 different evaluation points. HPV status was determined using p16 positivity as a surrogate marker. Univariate and multivariate statistical analyses were performed to identify whether p16 status is a significant predictor of functional outcome and QOL. Results One hundred twelve patients with OPSCC and known p16 status were treated with primary surgery between 1998 and 2009, with mean age of 56 years. Out of those patients 63 (56%) were p16 positive. Speech intelligibility remained high at 1-year post operation (95.4%). Only 11.5% of the patients required a feeding tube at 1 year after surgery to maintain their daily caloric requirements and the risk of aspiration after surgery was not significant (p = 0.097). There was no statistically or clinically significant difference in speech, swallowing ability, swallowing safety and QOL outcomes between p16-positive and negative OPSCC. Conclusions Surgically treated OPSCC patients demonstrate excellent swallowing function and can achieve excellent speech perception. P16 status may not be predictive of functional outcomes or QOL in surgically treated OPSCC. |
| format | Article |
| id | doaj-art-2411e121407843e8af159f841d03c17f |
| institution | Kabale University |
| issn | 1916-0216 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Otolaryngology - Head and Neck Surgery |
| spelling | doaj-art-2411e121407843e8af159f841d03c17f2025-02-03T10:54:12ZengSAGE PublishingJournal of Otolaryngology - Head and Neck Surgery1916-02162018-09-014711910.1186/s40463-018-0301-zThe impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstructionHani Z. Marzouki0Vincent L. Biron1Peter T. Dziegielewski2Andrew Ma3Jason Vaz4Gabriela Constantinescu5Jeffrey Harris6Daniel O’Connell7Hadi Seikaly8Department of Otolaryngology-Head and Neck Surgery, King Abdulaziz UniversityDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta and Alberta Health ServicesDepartment of Otolaryngology-Head and Neck Surgery, King Abdulaziz UniversityDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta and Alberta Health ServicesDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta and Alberta Health ServicesDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta and Alberta Health ServicesDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta and Alberta Health ServicesDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta and Alberta Health ServicesDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Alberta and Alberta Health ServicesAbstract Background To determine the impact of Human Papillomavirus (HPV) status on speech, swallowing, and quality of life (QOL) outcomes after surgical treatment of oropharyngeal cancer (OPSCC). Methods A retrospective review of a prospectively collected database of all patients with OPSCC diagnosed and treated from 1998 to 2009. Speech, swallowing, and quality of life data were gathered at 3 different evaluation points. HPV status was determined using p16 positivity as a surrogate marker. Univariate and multivariate statistical analyses were performed to identify whether p16 status is a significant predictor of functional outcome and QOL. Results One hundred twelve patients with OPSCC and known p16 status were treated with primary surgery between 1998 and 2009, with mean age of 56 years. Out of those patients 63 (56%) were p16 positive. Speech intelligibility remained high at 1-year post operation (95.4%). Only 11.5% of the patients required a feeding tube at 1 year after surgery to maintain their daily caloric requirements and the risk of aspiration after surgery was not significant (p = 0.097). There was no statistically or clinically significant difference in speech, swallowing ability, swallowing safety and QOL outcomes between p16-positive and negative OPSCC. Conclusions Surgically treated OPSCC patients demonstrate excellent swallowing function and can achieve excellent speech perception. P16 status may not be predictive of functional outcomes or QOL in surgically treated OPSCC.http://link.springer.com/article/10.1186/s40463-018-0301-z |
| spellingShingle | Hani Z. Marzouki Vincent L. Biron Peter T. Dziegielewski Andrew Ma Jason Vaz Gabriela Constantinescu Jeffrey Harris Daniel O’Connell Hadi Seikaly The impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstruction Journal of Otolaryngology - Head and Neck Surgery |
| title | The impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstruction |
| title_full | The impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstruction |
| title_fullStr | The impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstruction |
| title_full_unstemmed | The impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstruction |
| title_short | The impact of human papillomavirus (HPV) status on functional outcomes and quality of life (QOL) after surgical treatment of oropharyngeal carcinoma with free-flap reconstruction |
| title_sort | impact of human papillomavirus hpv status on functional outcomes and quality of life qol after surgical treatment of oropharyngeal carcinoma with free flap reconstruction |
| url | http://link.springer.com/article/10.1186/s40463-018-0301-z |
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