ACTH-Independent Cushing’s Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential
Adrenocortical oncocytomas are rare and mostly nonfunctioning neoplasms. We report the case of a 27-year-old woman diagnosed with an ACTH-independent Cushing’s syndrome due to left adrenal oncocytoma. She underwent laparoscopic adrenalectomy. Histopathological examination revealed an oncocytoma of u...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/8816527 |
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| author | Giuseppe S. Sica Leandro Siragusa Bruno Sensi Vittoria Bellato Pierangela Floris Valentina Rovella Alessandro Mauriello Monia Di Prete Rossana Telesca Valerio Ciavoni Carmine Cardillo Nicola Di Daniele Manfredi Tesauro |
| author_facet | Giuseppe S. Sica Leandro Siragusa Bruno Sensi Vittoria Bellato Pierangela Floris Valentina Rovella Alessandro Mauriello Monia Di Prete Rossana Telesca Valerio Ciavoni Carmine Cardillo Nicola Di Daniele Manfredi Tesauro |
| author_sort | Giuseppe S. Sica |
| collection | DOAJ |
| description | Adrenocortical oncocytomas are rare and mostly nonfunctioning neoplasms. We report the case of a 27-year-old woman diagnosed with an ACTH-independent Cushing’s syndrome due to left adrenal oncocytoma. She underwent laparoscopic adrenalectomy. Histopathological examination revealed an oncocytoma of uncertain malignant potential with a low Ki-67 proliferation index, inhibin A positivity, and chromogranin A negativity. Electron micrographs confirmed adrenal oncocytoma cells, characterized by the presence of a large amount of mitochondria. The postoperative course was uneventful, and the patient experienced a progressive regression of Cushing-related symptoms. Periodical follow-ups with MRI and cortisol dosage are required due to the neoplasm’s uncertain malignant potential. Considerations on the diagnosis, pathology findings, clinical remarks, and interventions are made. |
| format | Article |
| id | doaj-art-2410459fbf784ae092482f3cb9925f71 |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-2410459fbf784ae092482f3cb9925f712025-02-03T01:24:56ZengWileyCase Reports in Endocrinology2090-65012090-651X2020-01-01202010.1155/2020/88165278816527ACTH-Independent Cushing’s Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant PotentialGiuseppe S. Sica0Leandro Siragusa1Bruno Sensi2Vittoria Bellato3Pierangela Floris4Valentina Rovella5Alessandro Mauriello6Monia Di Prete7Rossana Telesca8Valerio Ciavoni9Carmine Cardillo10Nicola Di Daniele11Manfredi Tesauro12Department of Surgery, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Surgery, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Surgery, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Surgery, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Experimental Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Experimental Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Experimental Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Internal Medicine, Universitá Cattolica del Sacro Cuore, Rome 00168, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyAdrenocortical oncocytomas are rare and mostly nonfunctioning neoplasms. We report the case of a 27-year-old woman diagnosed with an ACTH-independent Cushing’s syndrome due to left adrenal oncocytoma. She underwent laparoscopic adrenalectomy. Histopathological examination revealed an oncocytoma of uncertain malignant potential with a low Ki-67 proliferation index, inhibin A positivity, and chromogranin A negativity. Electron micrographs confirmed adrenal oncocytoma cells, characterized by the presence of a large amount of mitochondria. The postoperative course was uneventful, and the patient experienced a progressive regression of Cushing-related symptoms. Periodical follow-ups with MRI and cortisol dosage are required due to the neoplasm’s uncertain malignant potential. Considerations on the diagnosis, pathology findings, clinical remarks, and interventions are made.http://dx.doi.org/10.1155/2020/8816527 |
| spellingShingle | Giuseppe S. Sica Leandro Siragusa Bruno Sensi Vittoria Bellato Pierangela Floris Valentina Rovella Alessandro Mauriello Monia Di Prete Rossana Telesca Valerio Ciavoni Carmine Cardillo Nicola Di Daniele Manfredi Tesauro ACTH-Independent Cushing’s Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential Case Reports in Endocrinology |
| title | ACTH-Independent Cushing’s Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential |
| title_full | ACTH-Independent Cushing’s Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential |
| title_fullStr | ACTH-Independent Cushing’s Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential |
| title_full_unstemmed | ACTH-Independent Cushing’s Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential |
| title_short | ACTH-Independent Cushing’s Syndrome Associated with Left Adrenocortical Oncocytoma of Uncertain Malignant Potential |
| title_sort | acth independent cushing s syndrome associated with left adrenocortical oncocytoma of uncertain malignant potential |
| url | http://dx.doi.org/10.1155/2020/8816527 |
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