Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract
Inflammation is a multifaceted process involving a host of resident and recruited immune cells that eliminate the insult or injury and initiate tissue repair. In the female reproductive tract (FMRT), inflammation-mediated alterations in epithelial, vascular, and immune functions are important compon...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/9707252 |
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| author | Anthonio O. Adefuye Henry A. Adeola Kurt J. Sales Arieh A. Katz |
| author_facet | Anthonio O. Adefuye Henry A. Adeola Kurt J. Sales Arieh A. Katz |
| author_sort | Anthonio O. Adefuye |
| collection | DOAJ |
| description | Inflammation is a multifaceted process involving a host of resident and recruited immune cells that eliminate the insult or injury and initiate tissue repair. In the female reproductive tract (FMRT), inflammation-mediated alterations in epithelial, vascular, and immune functions are important components of complex physiological processes and many local and systemic pathologies. It is well established that intracoital and postcoital function of seminal fluid (SF) goes beyond nutritive support for the spermatozoa cells. SF, in particular, the inflammatory bioactive lipids, and prostaglandins present in vast quantities in SF, have a role in localized immune modulation and regulation of pathways that can exacerbate inflammation in the FMRT. In sexually active women SF-mediated inflammation has been implicated in physiologic processes such as ovulation, implantation, and parturition while also enhancing tumorigenesis and susceptibility to infection. This review highlights the molecular mechanism by which SF regulates inflammatory pathways in the FMRT and how alterations in these pathways contribute to physiology and pathology of the female reproductive function. In addition, based on findings from TaqMan® 96-Well Plate Arrays, on neoplastic cervical cells treated with SF, we discuss new findings on the role of SF as a potent driver of inflammatory and tumorigenic pathways in the cervix. |
| format | Article |
| id | doaj-art-240ca9bed76d4f3ba8056a8ec8a05514 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-240ca9bed76d4f3ba8056a8ec8a055142025-02-03T07:24:54ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/97072529707252Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive TractAnthonio O. Adefuye0Henry A. Adeola1Kurt J. Sales2Arieh A. Katz3Division of Immunology, Department of Pathology, University of Cape Town, Faculty of Health Sciences, Observatory 7925, South AfricaInternational Centre for Genetic Engineering and Biotechnology and Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South AfricaMRC/UCT Receptor Biology Research Unit, Department of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South AfricaMRC/UCT Receptor Biology Research Unit, Department of Integrative Biomedical Sciences and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South AfricaInflammation is a multifaceted process involving a host of resident and recruited immune cells that eliminate the insult or injury and initiate tissue repair. In the female reproductive tract (FMRT), inflammation-mediated alterations in epithelial, vascular, and immune functions are important components of complex physiological processes and many local and systemic pathologies. It is well established that intracoital and postcoital function of seminal fluid (SF) goes beyond nutritive support for the spermatozoa cells. SF, in particular, the inflammatory bioactive lipids, and prostaglandins present in vast quantities in SF, have a role in localized immune modulation and regulation of pathways that can exacerbate inflammation in the FMRT. In sexually active women SF-mediated inflammation has been implicated in physiologic processes such as ovulation, implantation, and parturition while also enhancing tumorigenesis and susceptibility to infection. This review highlights the molecular mechanism by which SF regulates inflammatory pathways in the FMRT and how alterations in these pathways contribute to physiology and pathology of the female reproductive function. In addition, based on findings from TaqMan® 96-Well Plate Arrays, on neoplastic cervical cells treated with SF, we discuss new findings on the role of SF as a potent driver of inflammatory and tumorigenic pathways in the cervix.http://dx.doi.org/10.1155/2016/9707252 |
| spellingShingle | Anthonio O. Adefuye Henry A. Adeola Kurt J. Sales Arieh A. Katz Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract Journal of Immunology Research |
| title | Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract |
| title_full | Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract |
| title_fullStr | Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract |
| title_full_unstemmed | Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract |
| title_short | Seminal Fluid-Mediated Inflammation in Physiology and Pathology of the Female Reproductive Tract |
| title_sort | seminal fluid mediated inflammation in physiology and pathology of the female reproductive tract |
| url | http://dx.doi.org/10.1155/2016/9707252 |
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