Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells
Magnetic Fe3O4 nanoparticles were synthesized from maize leaves and plantain peels extract mediators. Particles were characterized, and the inhibitory effects were studied on HeLa cells in vitro using cyclic voltammetry (CV). Voltammograms from the CV show that Fe3O4 NPs interaction with HeLa cells...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2020/2630735 |
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| author | Bernard Owusu Asimeng Emmanuel Nyankson Johnson Kwame Efavi Amartey Nii Amarkai Gloria Pokuaa Manu Elvis Tiburu |
| author_facet | Bernard Owusu Asimeng Emmanuel Nyankson Johnson Kwame Efavi Amartey Nii Amarkai Gloria Pokuaa Manu Elvis Tiburu |
| author_sort | Bernard Owusu Asimeng |
| collection | DOAJ |
| description | Magnetic Fe3O4 nanoparticles were synthesized from maize leaves and plantain peels extract mediators. Particles were characterized, and the inhibitory effects were studied on HeLa cells in vitro using cyclic voltammetry (CV). Voltammograms from the CV show that Fe3O4 NPs interaction with HeLa cells affected their electrochemical behavior. The nanoparticles formed with higher Fe3+/Fe2+ molar ratio (2.8 : 1) resulted in smaller crystallite sizes compared to those formed with lower Fe3+/Fe2+ molar ratio (1.4 : 1). The particles with the smallest crystallite size showed higher anodic peak currents, whereas the larger crystallite sizes resulted in lower anodic peak currents. The peak currents relate to cell inhibition and are confirmed by the half-maximum inhibitory concentration (IC50). The findings show that the particles have a different inhibitory mechanism on HeLa cells ion transfer and are promising to be further exploited for cancer treatment. |
| format | Article |
| id | doaj-art-240082edc73547fe9c2f0b44e361fc57 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-240082edc73547fe9c2f0b44e361fc572025-02-03T05:57:19ZengWileyInternational Journal of Biomaterials1687-87871687-87952020-01-01202010.1155/2020/26307352630735Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa CellsBernard Owusu Asimeng0Emmanuel Nyankson1Johnson Kwame Efavi2Amartey Nii Amarkai3Gloria Pokuaa Manu4Elvis Tiburu5University of Ghana, School of Engineering Sciences, Department of Biomedical Engineering, P.O. Box LG 74, Accra, GhanaUniversity of Ghana, School of Engineering Sciences, Department of Materials Science & Engineering, P.O. Box LG 74, Accra, GhanaUniversity of Ghana, School of Engineering Sciences, Department of Materials Science & Engineering, P.O. Box LG 74, Accra, GhanaUniversity of Ghana, School of Engineering Sciences, Department of Materials Science & Engineering, P.O. Box LG 74, Accra, GhanaUniversity of Ghana, School of Engineering Sciences, Department of Materials Science & Engineering, P.O. Box LG 74, Accra, GhanaUniversity of Ghana, School of Engineering Sciences, Department of Biomedical Engineering, P.O. Box LG 74, Accra, GhanaMagnetic Fe3O4 nanoparticles were synthesized from maize leaves and plantain peels extract mediators. Particles were characterized, and the inhibitory effects were studied on HeLa cells in vitro using cyclic voltammetry (CV). Voltammograms from the CV show that Fe3O4 NPs interaction with HeLa cells affected their electrochemical behavior. The nanoparticles formed with higher Fe3+/Fe2+ molar ratio (2.8 : 1) resulted in smaller crystallite sizes compared to those formed with lower Fe3+/Fe2+ molar ratio (1.4 : 1). The particles with the smallest crystallite size showed higher anodic peak currents, whereas the larger crystallite sizes resulted in lower anodic peak currents. The peak currents relate to cell inhibition and are confirmed by the half-maximum inhibitory concentration (IC50). The findings show that the particles have a different inhibitory mechanism on HeLa cells ion transfer and are promising to be further exploited for cancer treatment.http://dx.doi.org/10.1155/2020/2630735 |
| spellingShingle | Bernard Owusu Asimeng Emmanuel Nyankson Johnson Kwame Efavi Amartey Nii Amarkai Gloria Pokuaa Manu Elvis Tiburu Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells International Journal of Biomaterials |
| title | Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells |
| title_full | Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells |
| title_fullStr | Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells |
| title_full_unstemmed | Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells |
| title_short | Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells |
| title_sort | characterization and inhibitory effects of magnetic iron oxide nanoparticles synthesized from plant extracts on hela cells |
| url | http://dx.doi.org/10.1155/2020/2630735 |
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