Research progress on gastric cancer-associated microbiome and important microbial mechanisms
Gastric cancer (GC) remains one of the major threats to global health, imposing a substantial disease burden. Its pathogenesis is complex and likely influenced by the interplay of multiple environmental, genetic and microbial factors. Advances in rapidly evolving microbiome detection technologies su...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Lanzhou University Press
2025-06-01
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| Series: | 生物医学转化 |
| Subjects: | |
| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20250208?st=article_issue |
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| _version_ | 1849415606151938048 |
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| author | Jiang Xiaowen Zhang Jingying Zhou Tong Li Wenqing Pan Kaifeng Zhang Yang |
| author_facet | Jiang Xiaowen Zhang Jingying Zhou Tong Li Wenqing Pan Kaifeng Zhang Yang |
| author_sort | Jiang Xiaowen |
| collection | DOAJ |
| description | Gastric cancer (GC) remains one of the major threats to global health, imposing a substantial disease burden. Its pathogenesis is complex and likely influenced by the interplay of multiple environmental, genetic and microbial factors. Advances in rapidly evolving microbiome detection technologies suggest that the gastric mucosal microbiota including Helicobacter pylori, a key carcinogenic factor, may interact and play synergistic roles in gastric cancer initiation and progression. This review summarizes recent advances in GC-associated microbiome research, systematically organizing and analyzing the pivotal roles of gastric microbiota in cancer tumorigenesis, progression and prognosis. Furthermore, it examines the potential mechanisms by which the key gastric microbes may contribute to carcinogenesis, providing a scientific foundation for future etiological investigations and early diagnosis and prevention targeting microbiome-related GC. |
| format | Article |
| id | doaj-art-23fcb2b26fbd47c19145d74aa4565df4 |
| institution | Kabale University |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-23fcb2b26fbd47c19145d74aa4565df42025-08-20T03:33:27ZzhoLanzhou University Press生物医学转化2096-89652025-06-0162485810.12287/j.issn.2096-8965.20250207Research progress on gastric cancer-associated microbiome and important microbial mechanismsJiang Xiaowen0Zhang Jingying1Zhou Tong2Li Wenqing3Pan Kaifeng4Zhang Yang5State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142 , ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142 , ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142 , ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142 , ChinaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142 , ChinaKey Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142 , ChinaGastric cancer (GC) remains one of the major threats to global health, imposing a substantial disease burden. Its pathogenesis is complex and likely influenced by the interplay of multiple environmental, genetic and microbial factors. Advances in rapidly evolving microbiome detection technologies suggest that the gastric mucosal microbiota including Helicobacter pylori, a key carcinogenic factor, may interact and play synergistic roles in gastric cancer initiation and progression. This review summarizes recent advances in GC-associated microbiome research, systematically organizing and analyzing the pivotal roles of gastric microbiota in cancer tumorigenesis, progression and prognosis. Furthermore, it examines the potential mechanisms by which the key gastric microbes may contribute to carcinogenesis, providing a scientific foundation for future etiological investigations and early diagnosis and prevention targeting microbiome-related GC.http://swyxzh.ijournals.cn/swyxzh/article/html/20250208?st=article_issuegastric cancergastric microbiotafunctional mechanism |
| spellingShingle | Jiang Xiaowen Zhang Jingying Zhou Tong Li Wenqing Pan Kaifeng Zhang Yang Research progress on gastric cancer-associated microbiome and important microbial mechanisms 生物医学转化 gastric cancer gastric microbiota functional mechanism |
| title | Research progress on gastric cancer-associated microbiome and important microbial mechanisms |
| title_full | Research progress on gastric cancer-associated microbiome and important microbial mechanisms |
| title_fullStr | Research progress on gastric cancer-associated microbiome and important microbial mechanisms |
| title_full_unstemmed | Research progress on gastric cancer-associated microbiome and important microbial mechanisms |
| title_short | Research progress on gastric cancer-associated microbiome and important microbial mechanisms |
| title_sort | research progress on gastric cancer associated microbiome and important microbial mechanisms |
| topic | gastric cancer gastric microbiota functional mechanism |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20250208?st=article_issue |
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