Discovery of MAGL Inhibition by Lophine Derivatives: An Unexpected Finding from Chemiluminescent Assay Development

Discovery of MAGL Inhibition by Lophine Derivatives: An Unexpected Finding from Chemiluminescent Assay Development

The inhibitory effects of two novel lophine derivatives were unexpectedly discovered during the development of a chemiluminescent monoacylglycerol lipase (MAGL) assay. The proposed lophine derivatives were found to exhibit concentration-dependent inhibitory effects on MAGL with the octanoic and palm...

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Bibliographic Details
Main Authors: Roberta Ottria, Silvana Casati, Ornella Xynomilakis, Aleksandar Veselinović, Pierangela Ciuffreda
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Molecules
Subjects:
lophine derivatives
monoacylglycerol lipase
MAGL
chemiluminescence assay
enhancers
inhibitors
Online Access:https://www.mdpi.com/1420-3049/30/7/1605
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