Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment

Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment

Abstract Midkine (MDK), a multifunctional growth factor, has been implicated in promoting tumor progression, yet its role in glioblastoma (GBM) remains insufficiently characterized. To investigate MDK’s function in glioma, we integrated four RNA-Seq datasets into a harmonized cohort of 1,017 adult g...

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Bibliographic Details
Main Authors: Mieszko Lachota, Katarzyna Zielniok, Agata Góźdź, Patrycja Szpak, Ilona Kalaszczyńska, Radosław Zagożdżon
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Midkine
MDK
Glioblastoma
GBM
Glioma
Tumor microenvironment
Online Access:https://doi.org/10.1038/s41598-025-16253-5
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