Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation
We compared plasma levels of biomarkers of inflammation (CRP) and oxidation (oxLDL), determined at study inclusion in lone atrial fibrillation (LAF) patients (48.6±11.5 years; 74.0% men) and sinus rhythm controls (49.7±9.3 years; 72.7% men, P>0.05), and investigated the association of baseline CR...
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/653026 |
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| author | Marija M. Polovina Miodrag C. Ostojic Tatjana S. Potpara |
| author_facet | Marija M. Polovina Miodrag C. Ostojic Tatjana S. Potpara |
| author_sort | Marija M. Polovina |
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| description | We compared plasma levels of biomarkers of inflammation (CRP) and oxidation (oxLDL), determined at study inclusion in lone atrial fibrillation (LAF) patients (48.6±11.5 years; 74.0% men) and sinus rhythm controls (49.7±9.3 years; 72.7% men, P>0.05), and investigated the association of baseline CRP and oxLDL levels with the risk for vascular disease (VD) development (hypertension, cerebrovascular disease, coronary/peripheral artery disease, and pulmonary embolism) during prospective follow-up. Baseline CRP (1.2 [0.7–1.9] mg/L versus 1.1 [0.7–1.6] mg/L) and oxLDL levels (66.3±21.2 U/L versus 57.1±14.6 U/L) were higher in LAF patients (both P<0.05). Following a median of 36 months, incident VD occurred in 14 (28.0%) LAF patients, all of whom developed arterial hypertension, and in 5 (11.4%) controls (hypertension, n=4; coronary artery disease, n=1), P<0.05. LAF patients developed VD more frequently and at a younger age. Both CRP (HR, 2.54; 95% CI, 1.26–5.12; P=0.009) and oxLDL (HR, 2.24; 95% CI, 1.14–4.40; P=0.019) were multivariate predictors of incident hypertension in LAF patients, but not in the controls. Further research should clarify clinical relevance of investigated biomarkers for risk stratification and treatment of LAF patients. |
| format | Article |
| id | doaj-art-23efddcef26b4dbfa01449cea57ebdd1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
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| series | Mediators of Inflammation |
| spelling | doaj-art-23efddcef26b4dbfa01449cea57ebdd12025-02-03T06:00:53ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/653026653026Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial FibrillationMarija M. Polovina0Miodrag C. Ostojic1Tatjana S. Potpara2Cardiology Clinic, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, SerbiaSchool of Medicine, Belgrade University, Dr. Subotica 8, 11000 Belgrade, SerbiaCardiology Clinic, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, SerbiaWe compared plasma levels of biomarkers of inflammation (CRP) and oxidation (oxLDL), determined at study inclusion in lone atrial fibrillation (LAF) patients (48.6±11.5 years; 74.0% men) and sinus rhythm controls (49.7±9.3 years; 72.7% men, P>0.05), and investigated the association of baseline CRP and oxLDL levels with the risk for vascular disease (VD) development (hypertension, cerebrovascular disease, coronary/peripheral artery disease, and pulmonary embolism) during prospective follow-up. Baseline CRP (1.2 [0.7–1.9] mg/L versus 1.1 [0.7–1.6] mg/L) and oxLDL levels (66.3±21.2 U/L versus 57.1±14.6 U/L) were higher in LAF patients (both P<0.05). Following a median of 36 months, incident VD occurred in 14 (28.0%) LAF patients, all of whom developed arterial hypertension, and in 5 (11.4%) controls (hypertension, n=4; coronary artery disease, n=1), P<0.05. LAF patients developed VD more frequently and at a younger age. Both CRP (HR, 2.54; 95% CI, 1.26–5.12; P=0.009) and oxLDL (HR, 2.24; 95% CI, 1.14–4.40; P=0.019) were multivariate predictors of incident hypertension in LAF patients, but not in the controls. Further research should clarify clinical relevance of investigated biomarkers for risk stratification and treatment of LAF patients.http://dx.doi.org/10.1155/2015/653026 |
| spellingShingle | Marija M. Polovina Miodrag C. Ostojic Tatjana S. Potpara Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation Mediators of Inflammation |
| title | Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation |
| title_full | Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation |
| title_fullStr | Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation |
| title_full_unstemmed | Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation |
| title_short | Relation of Biomarkers of Inflammation and Oxidative Stress with Hypertension Occurrence in Lone Atrial Fibrillation |
| title_sort | relation of biomarkers of inflammation and oxidative stress with hypertension occurrence in lone atrial fibrillation |
| url | http://dx.doi.org/10.1155/2015/653026 |
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