Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids
Potentiometric titration method has been used to define stoichiometries and stability constants of ternary complexes of Cu(II) with duloxetine (D) and some selected amino acids (L). The protonation constants of the ligands and the stability constants of the binary and ternary complexes of Cu(II) wit...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2019/1064942 |
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| author | Amal M. Al-Mohaimeed Asma A. Alothman |
| author_facet | Amal M. Al-Mohaimeed Asma A. Alothman |
| author_sort | Amal M. Al-Mohaimeed |
| collection | DOAJ |
| description | Potentiometric titration method has been used to define stoichiometries and stability constants of ternary complexes of Cu(II) with duloxetine (D) and some selected amino acids (L). The protonation constants of the ligands and the stability constants of the binary and ternary complexes of Cu(II) with the ligands were calculated from the potentiometric data using the HYPERQUAD program. The formation constants of the complexes formed in aqueous solutions and their concentration distributions as a function of pH were evaluated at 25°C and ionic strength 0.10 mol·L−1 NaNO3. Respective stabilities of ternary complexes have been determined compared with the corresponding binary complexes in terms of Δlog K and %R.S. values. A novel binary and ternary duloxetine (D) drug with glycine and its Cu(II) complexes has been synthesized and characterized by several spectroscopic methods. Electronic spectra and magnetic susceptibility measurements reveal square planar geometry for both complexes. The elemental analyses and mass spectral data have justified the [Cu(D)(Gly)] and [Cu(D)Cl(H2O)] composition of complexes, where D = duloxetine and Gly = glycine. The EPR spectra of Cu(II) complexes support the mononuclear structures. Thermal properties and decomposition kinetics of Cu(II) complexes are investigated. |
| format | Article |
| id | doaj-art-23e6e2bae8994fedbb3072c1f9bcb222 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-23e6e2bae8994fedbb3072c1f9bcb2222025-02-03T01:11:05ZengWileyJournal of Chemistry2090-90632090-90712019-01-01201910.1155/2019/10649421064942Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino AcidsAmal M. Al-Mohaimeed0Asma A. Alothman1Department of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi ArabiaDepartment of Chemistry, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi ArabiaPotentiometric titration method has been used to define stoichiometries and stability constants of ternary complexes of Cu(II) with duloxetine (D) and some selected amino acids (L). The protonation constants of the ligands and the stability constants of the binary and ternary complexes of Cu(II) with the ligands were calculated from the potentiometric data using the HYPERQUAD program. The formation constants of the complexes formed in aqueous solutions and their concentration distributions as a function of pH were evaluated at 25°C and ionic strength 0.10 mol·L−1 NaNO3. Respective stabilities of ternary complexes have been determined compared with the corresponding binary complexes in terms of Δlog K and %R.S. values. A novel binary and ternary duloxetine (D) drug with glycine and its Cu(II) complexes has been synthesized and characterized by several spectroscopic methods. Electronic spectra and magnetic susceptibility measurements reveal square planar geometry for both complexes. The elemental analyses and mass spectral data have justified the [Cu(D)(Gly)] and [Cu(D)Cl(H2O)] composition of complexes, where D = duloxetine and Gly = glycine. The EPR spectra of Cu(II) complexes support the mononuclear structures. Thermal properties and decomposition kinetics of Cu(II) complexes are investigated.http://dx.doi.org/10.1155/2019/1064942 |
| spellingShingle | Amal M. Al-Mohaimeed Asma A. Alothman Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids Journal of Chemistry |
| title | Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids |
| title_full | Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids |
| title_fullStr | Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids |
| title_full_unstemmed | Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids |
| title_short | Characterization by Potentiometric Procedures of the Stability Constants of the Binary and Ternary Complexes of Cu(II) and Duloxetine Drug with Amino Acids |
| title_sort | characterization by potentiometric procedures of the stability constants of the binary and ternary complexes of cu ii and duloxetine drug with amino acids |
| url | http://dx.doi.org/10.1155/2019/1064942 |
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