Engineering aortic valves via transdifferentiating fibroblasts into valvular endothelial cells without using viruses or iPS cells

The technology of induced pluripotent stem cells (iPSCs) has enabled the conversion of somatic cells into primitive undifferentiated cells via reprogramming. This approach provides possibilities for cell replacement therapies and drug screening, but the potential risk of tumorigenesis hampers its fu...

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Bibliographic Details
Main Authors:	Peng Tang, Fuxiang Wei, Weihua Qiao, Xing Chen, Chenyang Ji, Wanzhi Yang, Xinyu Zhang, Sihan Chen, Yanyan Wu, Mingxing Jiang, Chenyu Ma, Weiqiang Shen, Qi Dong, Hong Cao, Minghui Xie, Ziwen Cai, Li Xu, Jiawei Shi, Nianguo Dong, Junwei Chen, Ning Wang
Format:	Article
Language:	English
Published:	KeAi Communications Co., Ltd. 2025-03-01
Series:	Bioactive Materials
Subjects:	Transdifferentiation Valvular endothelial cells Tissue engineered aortic valves Soluble factors, Substrate stiffness
Online Access:	http://www.sciencedirect.com/science/article/pii/S2452199X24005024
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Engineering aortic valves via transdifferentiating fibroblasts into valvular endothelial cells without using viruses or iPS cells

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