Fusobacterium nucleatum-driven CX3CR1+ PD-L1+ phagocytes route to tumor tissues and reshape tumor microenvironment

Fusobacterium nucleatum-driven CX3CR1+ PD-L1+ phagocytes route to tumor tissues and reshape tumor microenvironment

The intracellular bacterium Fusobacterium nucleatum (Fn) mediates tumorigenesis and progression in colorectal cancer (CRC). However, the origin of intratumoral Fn and the role of Fn-infected immunocytes in the tumor microenvironment remain unclear. Here, we observed that Fn-infected neutrophils/macr...

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Bibliographic Details
Main Authors: Fangfang Chen, Songhe Guo, Yiqiu Li, Yongfan Lu, Le Liu, Shengxin Chen, Jun An, Ge Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Fusobacterium nucleatum
phagocytes
Fn1792
CX3CR1+PD-L1+
tumor microenvironment
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2024.2442037
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