Brain White Matter Impairment in Patients with Spinal Cord Injury
It remains unknown whether spinal cord injury (SCI) could indirectly impair or reshape the white matter (WM) of human brain and whether these changes are correlated with injury severity, duration, or clinical performance. We choose tract-based spatial statistics (TBSS) to investigate the possible ch...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/4671607 |
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| author | Weimin Zheng Qian Chen Xin Chen Lu Wan Wen Qin Zhigang Qi Nan Chen Kuncheng Li |
| author_facet | Weimin Zheng Qian Chen Xin Chen Lu Wan Wen Qin Zhigang Qi Nan Chen Kuncheng Li |
| author_sort | Weimin Zheng |
| collection | DOAJ |
| description | It remains unknown whether spinal cord injury (SCI) could indirectly impair or reshape the white matter (WM) of human brain and whether these changes are correlated with injury severity, duration, or clinical performance. We choose tract-based spatial statistics (TBSS) to investigate the possible changes in whole-brain white matter integrity and their associations with clinical variables in fifteen patients with SCI. Compared with the healthy controls, the patients exhibited significant decreases in WM fractional anisotropy (FA) in the left angular gyrus (AG), right cerebellum (CB), left precentral gyrus (PreCG), left lateral occipital region (LOC), left superior longitudinal fasciculus (SLF), left supramarginal gyrus (SMG), and left postcentral gyrus (PostCG) (p<0.01, TFCE corrected). No significant differences were found in all diffusion indices between the complete and incomplete SCI. However, significantly negative correlation was shown between the increased radial diffusivity (RD) of left AG and total motor scores (uncorrected p<0.05). Our findings provide evidence that SCI can cause not only direct degeneration but also transneuronal degeneration of brain WM, and these changes may be irrespective of the injury severity. The affection of left AG on rehabilitation therapies need to be further researched in the future. |
| format | Article |
| id | doaj-art-23d441ab971e4e6e8c379c0caa62cfc1 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-23d441ab971e4e6e8c379c0caa62cfc12025-02-03T05:49:37ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/46716074671607Brain White Matter Impairment in Patients with Spinal Cord InjuryWeimin Zheng0Qian Chen1Xin Chen2Lu Wan3Wen Qin4Zhigang Qi5Nan Chen6Kuncheng Li7Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaBeijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, ChinaDepartment of Radiology, Tianjin Medical University General Hospital, Tianjin, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, ChinaIt remains unknown whether spinal cord injury (SCI) could indirectly impair or reshape the white matter (WM) of human brain and whether these changes are correlated with injury severity, duration, or clinical performance. We choose tract-based spatial statistics (TBSS) to investigate the possible changes in whole-brain white matter integrity and their associations with clinical variables in fifteen patients with SCI. Compared with the healthy controls, the patients exhibited significant decreases in WM fractional anisotropy (FA) in the left angular gyrus (AG), right cerebellum (CB), left precentral gyrus (PreCG), left lateral occipital region (LOC), left superior longitudinal fasciculus (SLF), left supramarginal gyrus (SMG), and left postcentral gyrus (PostCG) (p<0.01, TFCE corrected). No significant differences were found in all diffusion indices between the complete and incomplete SCI. However, significantly negative correlation was shown between the increased radial diffusivity (RD) of left AG and total motor scores (uncorrected p<0.05). Our findings provide evidence that SCI can cause not only direct degeneration but also transneuronal degeneration of brain WM, and these changes may be irrespective of the injury severity. The affection of left AG on rehabilitation therapies need to be further researched in the future.http://dx.doi.org/10.1155/2017/4671607 |
| spellingShingle | Weimin Zheng Qian Chen Xin Chen Lu Wan Wen Qin Zhigang Qi Nan Chen Kuncheng Li Brain White Matter Impairment in Patients with Spinal Cord Injury Neural Plasticity |
| title | Brain White Matter Impairment in Patients with Spinal Cord Injury |
| title_full | Brain White Matter Impairment in Patients with Spinal Cord Injury |
| title_fullStr | Brain White Matter Impairment in Patients with Spinal Cord Injury |
| title_full_unstemmed | Brain White Matter Impairment in Patients with Spinal Cord Injury |
| title_short | Brain White Matter Impairment in Patients with Spinal Cord Injury |
| title_sort | brain white matter impairment in patients with spinal cord injury |
| url | http://dx.doi.org/10.1155/2017/4671607 |
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