Urticaria and Angioedema – More than just Skin Deep!
Urticaria and angioedema are characterized by pruritic hives and sometimes swelling of deeper mucocutaneous layers. Urticaria is caused by release of histamine and other mediators from mast cells. A cut-off of six weeks distinguishes acute and chronic forms, as these seem to differ regarding etiolog...
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| Language: | English |
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AOSIS
2016-11-01
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| Series: | South African Family Practice |
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| Online Access: | https://safpj.co.za/index.php/safpj/article/view/4607 |
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| author | Jeanette Holtzhausen |
| author_facet | Jeanette Holtzhausen |
| author_sort | Jeanette Holtzhausen |
| collection | DOAJ |
| description | Urticaria and angioedema are characterized by pruritic hives and sometimes swelling of deeper mucocutaneous layers. Urticaria is caused by release of histamine and other mediators from mast cells. A cut-off of six weeks distinguishes acute and chronic forms, as these seem to differ regarding etiological and response patterns. Angioedema may be histaminergic or due to factors involving the bradykinin pathway. Medications such as ACE-Inhibitors or conditions affecting the C1-esterase inhibitor enzyme are potential causes.
Acute urticaria may be related to triggers such as infections, medications or food allergy. When occurring with systemic symptoms and a temporal relationship to food or drug ingestion, IgE mediated allergy could be considered.
Chronic Inducible Urticaria (CInd) is suspected on history and may be confirmed by provocation testing where physical and other specific trigger factors elicit the wheals.
The term Chronic Spontaneous Urticaria (CSU) is used when symptoms persist for more than six weeks in the absence of inducible factors. A single cause is seldom found but a thorough history and clinical evaluation may elicit trigger factors and associated medical conditions such as auto-immune or thyroid disorders. Indiscriminate food allergy testing is unhelpful, but additive intolerance may be implicated in some cases. Modern non-sedating antihistamines are the mainstay of treatment, and omalizumab or immunosuppressives may be considered for refractory cases. Emotional support is needed as the condition is associated with psychological distress.
If there are unusual features, vasculitis, auto-inflammatory or haematological conditions should be considered and skin biopsy or detailed immunological work-up may be indicated. |
| format | Article |
| id | doaj-art-23ccfc732e954c8c9dacc947bc2f7714 |
| institution | DOAJ |
| issn | 2078-6190 2078-6204 |
| language | English |
| publishDate | 2016-11-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Family Practice |
| spelling | doaj-art-23ccfc732e954c8c9dacc947bc2f77142025-08-20T03:06:53ZengAOSISSouth African Family Practice2078-61902078-62042016-11-01591323610.4102/safp.v59i1.46073695Urticaria and Angioedema – More than just Skin Deep!Jeanette Holtzhausen0University of Cape Town Lung InstituteUrticaria and angioedema are characterized by pruritic hives and sometimes swelling of deeper mucocutaneous layers. Urticaria is caused by release of histamine and other mediators from mast cells. A cut-off of six weeks distinguishes acute and chronic forms, as these seem to differ regarding etiological and response patterns. Angioedema may be histaminergic or due to factors involving the bradykinin pathway. Medications such as ACE-Inhibitors or conditions affecting the C1-esterase inhibitor enzyme are potential causes. Acute urticaria may be related to triggers such as infections, medications or food allergy. When occurring with systemic symptoms and a temporal relationship to food or drug ingestion, IgE mediated allergy could be considered. Chronic Inducible Urticaria (CInd) is suspected on history and may be confirmed by provocation testing where physical and other specific trigger factors elicit the wheals. The term Chronic Spontaneous Urticaria (CSU) is used when symptoms persist for more than six weeks in the absence of inducible factors. A single cause is seldom found but a thorough history and clinical evaluation may elicit trigger factors and associated medical conditions such as auto-immune or thyroid disorders. Indiscriminate food allergy testing is unhelpful, but additive intolerance may be implicated in some cases. Modern non-sedating antihistamines are the mainstay of treatment, and omalizumab or immunosuppressives may be considered for refractory cases. Emotional support is needed as the condition is associated with psychological distress. If there are unusual features, vasculitis, auto-inflammatory or haematological conditions should be considered and skin biopsy or detailed immunological work-up may be indicated.https://safpj.co.za/index.php/safpj/article/view/4607angioedemaurticariachronic spontaneousmast cellspruritusitchhistaminehivewhealsomalizumab |
| spellingShingle | Jeanette Holtzhausen Urticaria and Angioedema – More than just Skin Deep! South African Family Practice angioedema urticaria chronic spontaneous mast cells pruritus itch histamine hive wheals omalizumab |
| title | Urticaria and Angioedema – More than just Skin Deep! |
| title_full | Urticaria and Angioedema – More than just Skin Deep! |
| title_fullStr | Urticaria and Angioedema – More than just Skin Deep! |
| title_full_unstemmed | Urticaria and Angioedema – More than just Skin Deep! |
| title_short | Urticaria and Angioedema – More than just Skin Deep! |
| title_sort | urticaria and angioedema more than just skin deep |
| topic | angioedema urticaria chronic spontaneous mast cells pruritus itch histamine hive wheals omalizumab |
| url | https://safpj.co.za/index.php/safpj/article/view/4607 |
| work_keys_str_mv | AT jeanetteholtzhausen urticariaandangioedemamorethanjustskindeep |