Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia
Objectives. To describe cognitive assessment including social cognition in SPG4 patients. Methods. We reported a series of nine patients with SPG4 mutation with an extensive neuropsychological examination including social cognition assessment. Results. None of our patients presented with mental reta...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2016/6423461 |
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| _version_ | 1832560165601148928 |
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| author | Ludivine Chamard Sabrina Ferreira Alexa Pijoff Manon Silvestre Eric Berger Eloi Magnin |
| author_facet | Ludivine Chamard Sabrina Ferreira Alexa Pijoff Manon Silvestre Eric Berger Eloi Magnin |
| author_sort | Ludivine Chamard |
| collection | DOAJ |
| description | Objectives. To describe cognitive assessment including social cognition in SPG4 patients. Methods. We reported a series of nine patients with SPG4 mutation with an extensive neuropsychological examination including social cognition assessment. Results. None of our patients presented with mental retardation or dementia. All presented with mild cognitive impairment with a high frequency of attention deficit (100%), executive disorders (89%), and social cognition impairment (78%). An asymptomatic patient for motor skills presented with the same cognitive profile. No correlation was found in this small sample between cognitive impairment and motor impairment, age at disease onset, or disease duration. Conclusions. SPG4 phenotypes share some cognitive features of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Cognitive disorders including executive disorders and social cognition impairment are frequent in SPG4 patients and might sometimes occur before motor disorders. Therefore, cognitive functions including social cognition should be systematically assessed in order to improve the clinical management of this population. |
| format | Article |
| id | doaj-art-23c62014143b4adcbc01c9d069536d02 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-23c62014143b4adcbc01c9d069536d022025-02-03T01:28:11ZengWileyBehavioural Neurology0953-41801875-85842016-01-01201610.1155/2016/64234616423461Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic ParaplegiaLudivine Chamard0Sabrina Ferreira1Alexa Pijoff2Manon Silvestre3Eric Berger4Eloi Magnin5University Hospital of Besançon, CH Jean Minjoz, Besançon, FranceUniversity Hospital of Besançon, CH Jean Minjoz, Besançon, FranceRegional Hospital of Dole, CH Louis Pasteur, Dole, FranceUniversity Hospital of Besançon, CH Jean Minjoz, Besançon, FranceUniversity Hospital of Besançon, CH Jean Minjoz, Besançon, FranceUniversity Hospital of Besançon, CH Jean Minjoz, Besançon, FranceObjectives. To describe cognitive assessment including social cognition in SPG4 patients. Methods. We reported a series of nine patients with SPG4 mutation with an extensive neuropsychological examination including social cognition assessment. Results. None of our patients presented with mental retardation or dementia. All presented with mild cognitive impairment with a high frequency of attention deficit (100%), executive disorders (89%), and social cognition impairment (78%). An asymptomatic patient for motor skills presented with the same cognitive profile. No correlation was found in this small sample between cognitive impairment and motor impairment, age at disease onset, or disease duration. Conclusions. SPG4 phenotypes share some cognitive features of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Cognitive disorders including executive disorders and social cognition impairment are frequent in SPG4 patients and might sometimes occur before motor disorders. Therefore, cognitive functions including social cognition should be systematically assessed in order to improve the clinical management of this population.http://dx.doi.org/10.1155/2016/6423461 |
| spellingShingle | Ludivine Chamard Sabrina Ferreira Alexa Pijoff Manon Silvestre Eric Berger Eloi Magnin Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia Behavioural Neurology |
| title | Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia |
| title_full | Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia |
| title_fullStr | Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia |
| title_full_unstemmed | Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia |
| title_short | Cognitive Impairment Involving Social Cognition in SPG4 Hereditary Spastic Paraplegia |
| title_sort | cognitive impairment involving social cognition in spg4 hereditary spastic paraplegia |
| url | http://dx.doi.org/10.1155/2016/6423461 |
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