Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis
In lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood concentrations of acylated ghrelin (AG), and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised. In t...
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| Format: | Article |
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Wiley
2016-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2016/2643625 |
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| author | Jessica Anne Douglas Kevin Deighton Jan Maria Atkinson Vahid Sari-Sarraf David John Stensel Greg Atkinson |
| author_facet | Jessica Anne Douglas Kevin Deighton Jan Maria Atkinson Vahid Sari-Sarraf David John Stensel Greg Atkinson |
| author_sort | Jessica Anne Douglas |
| collection | DOAJ |
| description | In lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood concentrations of acylated ghrelin (AG), and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised. In this systematic review and meta-analysis, we quantified the effects that acute exercise has on AG and total PYY and GLP-1 in overweight/obese individuals. The potential for body mass index (BMI) to act as a moderator for AG was also explored. Six published studies (73 participants, 78% male, mean BMI: 30.6 kg·m−2) met the inclusion criteria. Standardised mean differences (SMDs) and standard errors were extracted for AG and total PYY and GLP-1 concentrations in control and exercise trials and synthesised using a random effects meta-analysis model. BMI was the predictor in metaregression for AG. Exercise moderately suppressed AG area-under-the-curve concentrations (pooled SMD: −0.34, 95% CI: −0.53 to −0.15). The magnitude of this reduction was greater for higher mean BMIs (pooled metaregression slope: −0.04 SMD/kg·m−2 (95% CI: −0.07 to 0.00)). Trivial SMDs were obtained for total PYY (0.10, 95% CI: −0.13 to 0.31) and GLP-1 (−0.03, 95% CI: −0.18 to 0.13). This indicates that exercise in overweight/obese individuals moderately alters AG in a direction that could be associated with decreased hunger and energy intake. This trial is registered with PROSPERO: CRD42014006265. |
| format | Article |
| id | doaj-art-23c423c2cb9f449d84d85b77f54deb8d |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-23c423c2cb9f449d84d85b77f54deb8d2025-02-03T01:12:09ZengWileyJournal of Obesity2090-07082090-07162016-01-01201610.1155/2016/26436252643625Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-AnalysisJessica Anne Douglas0Kevin Deighton1Jan Maria Atkinson2Vahid Sari-Sarraf3David John Stensel4Greg Atkinson5School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UKInstitute for Sport, Physical Activity & Leisure, Leeds Beckett University, Leeds, UKHealth and Social Care Institute, Teesside University, Middlesbrough, UKDepartment of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, IranSchool of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UKHealth and Social Care Institute, Teesside University, Middlesbrough, UKIn lean individuals, acute aerobic exercise is reported to transiently suppress sensations of appetite, suppress blood concentrations of acylated ghrelin (AG), and increase glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY). Findings in overweight/obese individuals have yet to be synthesised. In this systematic review and meta-analysis, we quantified the effects that acute exercise has on AG and total PYY and GLP-1 in overweight/obese individuals. The potential for body mass index (BMI) to act as a moderator for AG was also explored. Six published studies (73 participants, 78% male, mean BMI: 30.6 kg·m−2) met the inclusion criteria. Standardised mean differences (SMDs) and standard errors were extracted for AG and total PYY and GLP-1 concentrations in control and exercise trials and synthesised using a random effects meta-analysis model. BMI was the predictor in metaregression for AG. Exercise moderately suppressed AG area-under-the-curve concentrations (pooled SMD: −0.34, 95% CI: −0.53 to −0.15). The magnitude of this reduction was greater for higher mean BMIs (pooled metaregression slope: −0.04 SMD/kg·m−2 (95% CI: −0.07 to 0.00)). Trivial SMDs were obtained for total PYY (0.10, 95% CI: −0.13 to 0.31) and GLP-1 (−0.03, 95% CI: −0.18 to 0.13). This indicates that exercise in overweight/obese individuals moderately alters AG in a direction that could be associated with decreased hunger and energy intake. This trial is registered with PROSPERO: CRD42014006265.http://dx.doi.org/10.1155/2016/2643625 |
| spellingShingle | Jessica Anne Douglas Kevin Deighton Jan Maria Atkinson Vahid Sari-Sarraf David John Stensel Greg Atkinson Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis Journal of Obesity |
| title | Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis |
| title_full | Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis |
| title_fullStr | Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis |
| title_full_unstemmed | Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis |
| title_short | Acute Exercise and Appetite-Regulating Hormones in Overweight and Obese Individuals: A Meta-Analysis |
| title_sort | acute exercise and appetite regulating hormones in overweight and obese individuals a meta analysis |
| url | http://dx.doi.org/10.1155/2016/2643625 |
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