Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood
ABSTRACT The relationship between the famine and metabolic syndrome has been reported, but there is a lack of more detailed changes in metabolic profiles. It is unclear how famine affects body composition. This study included 21,142 participants from the China National Health Survey. The body mass i...
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| Format: | Article |
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Wiley
2025-04-01
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| Series: | Maternal and Child Nutrition |
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| Online Access: | https://doi.org/10.1111/mcn.13777 |
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| author | Shuaihua Song Liyuan Zhang Hanze Du Yuelun Zhang Yue Jiang Daowei Li Yi Hu Shi Chen Huijuan Zhu Guangliang Shan Hui Pan |
| author_facet | Shuaihua Song Liyuan Zhang Hanze Du Yuelun Zhang Yue Jiang Daowei Li Yi Hu Shi Chen Huijuan Zhu Guangliang Shan Hui Pan |
| author_sort | Shuaihua Song |
| collection | DOAJ |
| description | ABSTRACT The relationship between the famine and metabolic syndrome has been reported, but there is a lack of more detailed changes in metabolic profiles. It is unclear how famine affects body composition. This study included 21,142 participants from the China National Health Survey. The body mass index (BMI), fat mass index (FMI), and fat‐free mass index (FFMI) were calculated. Systolic blood pressure (SBP), diastolic blood pressure (DBP), blood lipids, and fasting blood glucose (FBG) were measured. Multivariate adjusted linear regression models were used to assess the association between famine and outcome. Our results shown that fetal‐exposed group had higher BMI and FMI (β > 0). Childhood‐exposed group showed an average decrease of 0.08 standard deviation (SD) in FFMI, and adolescence‐exposed group had lower BMI and FFMI than non‐exposed group. SBP were 0.38 SD higher in fetal‐exposed group, 0.58 SD higher in childhood‐exposed group and 0.85 SD higher in adolescence‐exposed group than non‐exposed group. Famine‐exposed groups had higher total cholesterol (TC), low density lipoprotein‐cholesterol (LDL‐C), and FBG levels (β > 0). For females with famine exposure, they had a higher BMI, FMI, LDL‐C, TG, and TC than males. Overall, early famine exposure is associated with increased blood pressure, LDL‐C, TC, and FBG. Muscle mass loss in adulthood associated with childhood and adolescence famine exposure. Famine‐exposed females appear to have higher levels of body fat and blood lipids. |
| format | Article |
| id | doaj-art-23bd8e86c4cd4aae8beee04cf686459d |
| institution | DOAJ |
| issn | 1740-8695 1740-8709 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Maternal and Child Nutrition |
| spelling | doaj-art-23bd8e86c4cd4aae8beee04cf686459d2025-08-20T03:06:32ZengWileyMaternal and Child Nutrition1740-86951740-87092025-04-01212n/an/a10.1111/mcn.13777Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in AdulthoodShuaihua Song0Liyuan Zhang1Hanze Du2Yuelun Zhang3Yue Jiang4Daowei Li5Yi Hu6Shi Chen7Huijuan Zhu8Guangliang Shan9Hui Pan10Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing ChinaKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing ChinaKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing ChinaCenter for Prevention and Early Intervention, National Infrastructures for Translational Medicine, Institute of Clinical Medicine Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College Beijing ChinaKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing ChinaJilin Provincial Key Laboratory of Tooth Development and Bone Remodeling School and Hospital of Stomatology, Jilin University Changchun ChinaState Key Laboratory of Complex, Severe, and Rare Diseases, Biomedical Engineering Facility of National Infrastructures for Translational Medicine Peking Union Medical College Hospital Beijing ChinaKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing ChinaKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing ChinaDepartment of Epidemiology and Statistics Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College Beijing ChinaKey Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College Beijing ChinaABSTRACT The relationship between the famine and metabolic syndrome has been reported, but there is a lack of more detailed changes in metabolic profiles. It is unclear how famine affects body composition. This study included 21,142 participants from the China National Health Survey. The body mass index (BMI), fat mass index (FMI), and fat‐free mass index (FFMI) were calculated. Systolic blood pressure (SBP), diastolic blood pressure (DBP), blood lipids, and fasting blood glucose (FBG) were measured. Multivariate adjusted linear regression models were used to assess the association between famine and outcome. Our results shown that fetal‐exposed group had higher BMI and FMI (β > 0). Childhood‐exposed group showed an average decrease of 0.08 standard deviation (SD) in FFMI, and adolescence‐exposed group had lower BMI and FFMI than non‐exposed group. SBP were 0.38 SD higher in fetal‐exposed group, 0.58 SD higher in childhood‐exposed group and 0.85 SD higher in adolescence‐exposed group than non‐exposed group. Famine‐exposed groups had higher total cholesterol (TC), low density lipoprotein‐cholesterol (LDL‐C), and FBG levels (β > 0). For females with famine exposure, they had a higher BMI, FMI, LDL‐C, TG, and TC than males. Overall, early famine exposure is associated with increased blood pressure, LDL‐C, TC, and FBG. Muscle mass loss in adulthood associated with childhood and adolescence famine exposure. Famine‐exposed females appear to have higher levels of body fat and blood lipids.https://doi.org/10.1111/mcn.13777adulthoodbody compositionfaminemalnutritionmetabolic profiles |
| spellingShingle | Shuaihua Song Liyuan Zhang Hanze Du Yuelun Zhang Yue Jiang Daowei Li Yi Hu Shi Chen Huijuan Zhu Guangliang Shan Hui Pan Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood Maternal and Child Nutrition adulthood body composition famine malnutrition metabolic profiles |
| title | Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood |
| title_full | Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood |
| title_fullStr | Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood |
| title_full_unstemmed | Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood |
| title_short | Impact of Early Life Famine Exposure on Body Composition and Metabolic Profiles in Adulthood |
| title_sort | impact of early life famine exposure on body composition and metabolic profiles in adulthood |
| topic | adulthood body composition famine malnutrition metabolic profiles |
| url | https://doi.org/10.1111/mcn.13777 |
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