Aspergillus-Related Lung Disease
Aspergillus is a ubiquitous dimorphic fungus that causes a variety of human diseases ranging in severity from trivial to life-threatening, depending on the host response. An intact host defence is important to prevent disease, but individuals with pre-existing structural lung disease, atopy, occupat...
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| Format: | Article |
| Language: | English |
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Wiley
2005-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2005/759070 |
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| _version_ | 1832560165111463936 |
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| author | Alia Al-Alawi C Frank Ryan Julia D Flint Nestor L Müller |
| author_facet | Alia Al-Alawi C Frank Ryan Julia D Flint Nestor L Müller |
| author_sort | Alia Al-Alawi |
| collection | DOAJ |
| description | Aspergillus is a ubiquitous dimorphic fungus that causes a variety of human diseases ranging in severity from trivial to life-threatening, depending on the host response. An intact host defence is important to prevent disease, but individuals with pre-existing structural lung disease, atopy, occupational exposure or impaired immunity are susceptible. Three distinctive patterns of aspergillus-related lung disease are recognized: saprophytic infestation of airways, cavities and necrotic tissue; allergic disease including extrinsic allergic alveolitis, asthma, allergic bronchopulmonary aspergillosis, bronchocentric granulomatosis and chronic eosinophilic pneumonia; and airway and tissue invasive disease -- pseudomembranous tracheobronchitis, acute bronchopneumonia, angioinvasive aspergillosis, chronic necrotizing aspergillosis and invasive pleural disease. A broad knowledge of these clinical presentations and a high index of suspicion are required to ensure timely diagnosis and treatment of the potentially lethal manifestations of aspergillus-related pulmonary disease. In the present report, the clinical, radiographic and pathological aspects of the various aspergillus-related lung diseases are briefly reviewed. |
| format | Article |
| id | doaj-art-23a552080f6849958e643d12d3bdb445 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-23a552080f6849958e643d12d3bdb4452025-02-03T01:28:12ZengWileyCanadian Respiratory Journal1198-22412005-01-0112737738710.1155/2005/759070Aspergillus-Related Lung DiseaseAlia Al-Alawi0C Frank Ryan1Julia D Flint2Nestor L Müller3Division of Respiratory Medicine, Department of Medicine, Amiri Hospital, Safat, KuwaitDivision of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Pathology, University of British Columbia, Vancouver, British Columbia, CanadaDepartment of Radiology, University of British Columbia, Vancouver, British Columbia, CanadaAspergillus is a ubiquitous dimorphic fungus that causes a variety of human diseases ranging in severity from trivial to life-threatening, depending on the host response. An intact host defence is important to prevent disease, but individuals with pre-existing structural lung disease, atopy, occupational exposure or impaired immunity are susceptible. Three distinctive patterns of aspergillus-related lung disease are recognized: saprophytic infestation of airways, cavities and necrotic tissue; allergic disease including extrinsic allergic alveolitis, asthma, allergic bronchopulmonary aspergillosis, bronchocentric granulomatosis and chronic eosinophilic pneumonia; and airway and tissue invasive disease -- pseudomembranous tracheobronchitis, acute bronchopneumonia, angioinvasive aspergillosis, chronic necrotizing aspergillosis and invasive pleural disease. A broad knowledge of these clinical presentations and a high index of suspicion are required to ensure timely diagnosis and treatment of the potentially lethal manifestations of aspergillus-related pulmonary disease. In the present report, the clinical, radiographic and pathological aspects of the various aspergillus-related lung diseases are briefly reviewed.http://dx.doi.org/10.1155/2005/759070 |
| spellingShingle | Alia Al-Alawi C Frank Ryan Julia D Flint Nestor L Müller Aspergillus-Related Lung Disease Canadian Respiratory Journal |
| title | Aspergillus-Related Lung Disease |
| title_full | Aspergillus-Related Lung Disease |
| title_fullStr | Aspergillus-Related Lung Disease |
| title_full_unstemmed | Aspergillus-Related Lung Disease |
| title_short | Aspergillus-Related Lung Disease |
| title_sort | aspergillus related lung disease |
| url | http://dx.doi.org/10.1155/2005/759070 |
| work_keys_str_mv | AT aliaalalawi aspergillusrelatedlungdisease AT cfrankryan aspergillusrelatedlungdisease AT juliadflint aspergillusrelatedlungdisease AT nestorlmuller aspergillusrelatedlungdisease |