Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome
A 45-year-old female was diagnosed with Hashimoto’s thyroiditis in 1976 and Addison’s disease in 1979. At that time, her antimitochondrial antibody (AMA) level was elevated at 1:32. She subsequently developed premature ovarian failure and type I diabetes mellitus. In 1996, she became jaundiced with...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1999-01-01
|
| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1999/810264 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566741192933376 |
|---|---|
| author | Mark Ram Borgaonkar David Geoffrey Morgan |
| author_facet | Mark Ram Borgaonkar David Geoffrey Morgan |
| author_sort | Mark Ram Borgaonkar |
| collection | DOAJ |
| description | A 45-year-old female was diagnosed with Hashimoto’s thyroiditis in 1976 and Addison’s disease in 1979. At that time, her antimitochondrial antibody (AMA) level was elevated at 1:32. She subsequently developed premature ovarian failure and type I diabetes mellitus. In 1996, she became jaundiced with a cholestatic enzyme pattern. AMA was positive at a titre of 1:256. A liver biopsy confirmed the diagnosis of primary biliary cirrhosis (PBC). She underwent a liver transplantation in January 1998. This is the first report of PBC in association with type II autoimmune polyglandular syndrome. The association of PBC with other organ-specific autoimmune diseases supports an immune-mediated pathogenesis and may have implications in further studies of PBC. |
| format | Article |
| id | doaj-art-239bd4b77dd844ea8d3403c676036751 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-239bd4b77dd844ea8d3403c6760367512025-02-03T01:03:15ZengWileyCanadian Journal of Gastroenterology0835-79001999-01-0113976777010.1155/1999/810264Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular SyndromeMark Ram Borgaonkar0David Geoffrey Morgan1Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, CanadaDepartment of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Ontario, CanadaA 45-year-old female was diagnosed with Hashimoto’s thyroiditis in 1976 and Addison’s disease in 1979. At that time, her antimitochondrial antibody (AMA) level was elevated at 1:32. She subsequently developed premature ovarian failure and type I diabetes mellitus. In 1996, she became jaundiced with a cholestatic enzyme pattern. AMA was positive at a titre of 1:256. A liver biopsy confirmed the diagnosis of primary biliary cirrhosis (PBC). She underwent a liver transplantation in January 1998. This is the first report of PBC in association with type II autoimmune polyglandular syndrome. The association of PBC with other organ-specific autoimmune diseases supports an immune-mediated pathogenesis and may have implications in further studies of PBC.http://dx.doi.org/10.1155/1999/810264 |
| spellingShingle | Mark Ram Borgaonkar David Geoffrey Morgan Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome Canadian Journal of Gastroenterology |
| title | Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome |
| title_full | Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome |
| title_fullStr | Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome |
| title_full_unstemmed | Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome |
| title_short | Primary Biliary Cirrhosis and Type II Autoimmune Polyglandular Syndrome |
| title_sort | primary biliary cirrhosis and type ii autoimmune polyglandular syndrome |
| url | http://dx.doi.org/10.1155/1999/810264 |
| work_keys_str_mv | AT markramborgaonkar primarybiliarycirrhosisandtypeiiautoimmunepolyglandularsyndrome AT davidgeoffreymorgan primarybiliarycirrhosisandtypeiiautoimmunepolyglandularsyndrome |