Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma
Vinorelbine (Navelbine, VRL) is commonly used for platinum-resistant ovarian cancer and has been shown to be effective in patients with recurrent primary peritoneal carcinoma. Of VRL’s major side effects, skin rash is uncommon, and, if it does occur, it is usually localized to site of injection. In...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/825717 |
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| author | Mustafa M. Mohammad Kostas N. Syrigos M. Wasif Saif |
| author_facet | Mustafa M. Mohammad Kostas N. Syrigos M. Wasif Saif |
| author_sort | Mustafa M. Mohammad |
| collection | DOAJ |
| description | Vinorelbine (Navelbine, VRL) is commonly used for platinum-resistant ovarian cancer and has been shown to be effective in patients with recurrent primary peritoneal carcinoma. Of VRL’s major side effects, skin rash is uncommon, and, if it does occur, it is usually localized to site of injection. In this case report, a 71-year-old Hispanic female with primary peritoneal carcinoma received single agent VRL as fourth-line regimen, which she tolerated very well except for a skin rash related to VRL. The rash continued to progress throughout 6 cycles of VRL, and follow-up CT/PET scan demonstrated complete metabolic and radiological responses. We, therefore, believe that this rash was linked to VRL administration and correlated with response to therapy. Rash has been recognized as a useful surrogate marker with targeted agents such as cetuximab and erlotinib; to the best of our knowledge, this case report describes the first patient with a possible drug rash and its association with a positive outcome. This case report incites interest in further investigation of similar cases to support this observation, since there is a lack of reports of skin rash with VRL therapy. |
| format | Article |
| id | doaj-art-2394925b866d40c5a3cafef54d3d4aa9 |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-2394925b866d40c5a3cafef54d3d4aa92025-02-03T01:07:53ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712013-01-01201310.1155/2013/825717825717Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal CarcinomaMustafa M. Mohammad0Kostas N. Syrigos1M. Wasif Saif2Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02110, USADepartment of Oncology, Sotiria General Hospital, Athens, GreeceTufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02110, USAVinorelbine (Navelbine, VRL) is commonly used for platinum-resistant ovarian cancer and has been shown to be effective in patients with recurrent primary peritoneal carcinoma. Of VRL’s major side effects, skin rash is uncommon, and, if it does occur, it is usually localized to site of injection. In this case report, a 71-year-old Hispanic female with primary peritoneal carcinoma received single agent VRL as fourth-line regimen, which she tolerated very well except for a skin rash related to VRL. The rash continued to progress throughout 6 cycles of VRL, and follow-up CT/PET scan demonstrated complete metabolic and radiological responses. We, therefore, believe that this rash was linked to VRL administration and correlated with response to therapy. Rash has been recognized as a useful surrogate marker with targeted agents such as cetuximab and erlotinib; to the best of our knowledge, this case report describes the first patient with a possible drug rash and its association with a positive outcome. This case report incites interest in further investigation of similar cases to support this observation, since there is a lack of reports of skin rash with VRL therapy.http://dx.doi.org/10.1155/2013/825717 |
| spellingShingle | Mustafa M. Mohammad Kostas N. Syrigos M. Wasif Saif Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma Case Reports in Dermatological Medicine |
| title | Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma |
| title_full | Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma |
| title_fullStr | Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma |
| title_full_unstemmed | Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma |
| title_short | Association between Rash and a Positive Drug Response Associated with Vinorelbine in a Patient with Primary Peritoneal Carcinoma |
| title_sort | association between rash and a positive drug response associated with vinorelbine in a patient with primary peritoneal carcinoma |
| url | http://dx.doi.org/10.1155/2013/825717 |
| work_keys_str_mv | AT mustafammohammad associationbetweenrashandapositivedrugresponseassociatedwithvinorelbineinapatientwithprimaryperitonealcarcinoma AT kostasnsyrigos associationbetweenrashandapositivedrugresponseassociatedwithvinorelbineinapatientwithprimaryperitonealcarcinoma AT mwasifsaif associationbetweenrashandapositivedrugresponseassociatedwithvinorelbineinapatientwithprimaryperitonealcarcinoma |