Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility
Reproductive functions may be altered by the exposure to a multitude of endogenous and exogenous agents, drug or environmental pollutants, which are known to affect gene transcription through the peroxisome proliferator-activated receptors (PPARs) activation. PPARs act as ligand activated transcript...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4612306 |
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| _version_ | 1832563966481530880 |
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| author | Maurizio Vitti Giovanna Di Emidio Michela Di Carlo Gaspare Carta Andrea Antonosante Paolo Giovanni Artini Annamaria Cimini Carla Tatone Elisabetta Benedetti |
| author_facet | Maurizio Vitti Giovanna Di Emidio Michela Di Carlo Gaspare Carta Andrea Antonosante Paolo Giovanni Artini Annamaria Cimini Carla Tatone Elisabetta Benedetti |
| author_sort | Maurizio Vitti |
| collection | DOAJ |
| description | Reproductive functions may be altered by the exposure to a multitude of endogenous and exogenous agents, drug or environmental pollutants, which are known to affect gene transcription through the peroxisome proliferator-activated receptors (PPARs) activation. PPARs act as ligand activated transcription factors and regulate metabolic processes such as lipid and glucose metabolism, energy homeostasis, inflammation, and cell proliferation and differentiation. All PPARs isotypes are expressed along the hypothalamic-pituitary-gonadal axis and are strictly involved in reproductive functions. Since female fertility and energy metabolism are tightly interconnected, the research on female infertility points towards the exploration of potential PPARs activating/antagonizing compounds, mainly belonging to the class of thiazolidinediones (TZDs) and fibrates, as useful agents for the maintenance of metabolic homeostasis in women with ovarian dysfunctions. In the present review, we discuss the recent evidence about PPARs expression in the hypothalamic-pituitary-gonadal axis and their involvement in female reproduction. Finally, the therapeutic potential of their manipulation through several drugs is also discussed. |
| format | Article |
| id | doaj-art-238a5a5c2ace4fac8eb2af7b4cac67cb |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-238a5a5c2ace4fac8eb2af7b4cac67cb2025-02-03T01:12:01ZengWileyPPAR Research1687-47571687-47652016-01-01201610.1155/2016/46123064612306Peroxisome Proliferator-Activated Receptors in Female Reproduction and FertilityMaurizio Vitti0Giovanna Di Emidio1Michela Di Carlo2Gaspare Carta3Andrea Antonosante4Paolo Giovanni Artini5Annamaria Cimini6Carla Tatone7Elisabetta Benedetti8Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Experimental and Clinical Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyReproductive functions may be altered by the exposure to a multitude of endogenous and exogenous agents, drug or environmental pollutants, which are known to affect gene transcription through the peroxisome proliferator-activated receptors (PPARs) activation. PPARs act as ligand activated transcription factors and regulate metabolic processes such as lipid and glucose metabolism, energy homeostasis, inflammation, and cell proliferation and differentiation. All PPARs isotypes are expressed along the hypothalamic-pituitary-gonadal axis and are strictly involved in reproductive functions. Since female fertility and energy metabolism are tightly interconnected, the research on female infertility points towards the exploration of potential PPARs activating/antagonizing compounds, mainly belonging to the class of thiazolidinediones (TZDs) and fibrates, as useful agents for the maintenance of metabolic homeostasis in women with ovarian dysfunctions. In the present review, we discuss the recent evidence about PPARs expression in the hypothalamic-pituitary-gonadal axis and their involvement in female reproduction. Finally, the therapeutic potential of their manipulation through several drugs is also discussed.http://dx.doi.org/10.1155/2016/4612306 |
| spellingShingle | Maurizio Vitti Giovanna Di Emidio Michela Di Carlo Gaspare Carta Andrea Antonosante Paolo Giovanni Artini Annamaria Cimini Carla Tatone Elisabetta Benedetti Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility PPAR Research |
| title | Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility |
| title_full | Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility |
| title_fullStr | Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility |
| title_full_unstemmed | Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility |
| title_short | Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility |
| title_sort | peroxisome proliferator activated receptors in female reproduction and fertility |
| url | http://dx.doi.org/10.1155/2016/4612306 |
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