Medical Management of Chronic Cholestatic Liver Diseases

The purpose of the present review is to discuss the diagnosis and management of cholestatic liver diseases. Differential diagnoses to consider are described, including causes of extrahepatic biliary obstruction such as gallstones, strictures, extrabiliary malignancies and pancreatitis. In addition,...

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Main Authors: Andrea A Gossard, Keith D Lindor
Format: Article
Language:English
Published: Wiley 2000-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2000/871543
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author Andrea A Gossard
Keith D Lindor
author_facet Andrea A Gossard
Keith D Lindor
author_sort Andrea A Gossard
collection DOAJ
description The purpose of the present review is to discuss the diagnosis and management of cholestatic liver diseases. Differential diagnoses to consider are described, including causes of extrahepatic biliary obstruction such as gallstones, strictures, extrabiliary malignancies and pancreatitis. In addition, diseases that cause intrahepatic cholestasis such as primary biliary cirrhosis, primary sclerosing cholangitis, hepatocellular diseases and a variety of miscellaneous causes including drugs that may cause cholestasis are discussed. Primary biliary cirrhosis and primary sclerosing cholangitis are reviewed in detail, and management options are identified. The prognosis of patients with these diseases is discussed, and the Mayo Mathematical Models in Cholestatic Liver Disease for both primary biliary cirrhosis and primary sclerosing cholangitis are provided. Finally, management options for the complications of cholestasis are provided.
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series Canadian Journal of Gastroenterology
spelling doaj-art-237d675d51ba4ff8bd6581bd9dc1342e2025-02-03T06:01:11ZengWileyCanadian Journal of Gastroenterology0835-79002000-01-0114Suppl D93D98D10.1155/2000/871543Medical Management of Chronic Cholestatic Liver DiseasesAndrea A Gossard0Keith D Lindor1Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota, USADivision of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota, USAThe purpose of the present review is to discuss the diagnosis and management of cholestatic liver diseases. Differential diagnoses to consider are described, including causes of extrahepatic biliary obstruction such as gallstones, strictures, extrabiliary malignancies and pancreatitis. In addition, diseases that cause intrahepatic cholestasis such as primary biliary cirrhosis, primary sclerosing cholangitis, hepatocellular diseases and a variety of miscellaneous causes including drugs that may cause cholestasis are discussed. Primary biliary cirrhosis and primary sclerosing cholangitis are reviewed in detail, and management options are identified. The prognosis of patients with these diseases is discussed, and the Mayo Mathematical Models in Cholestatic Liver Disease for both primary biliary cirrhosis and primary sclerosing cholangitis are provided. Finally, management options for the complications of cholestasis are provided.http://dx.doi.org/10.1155/2000/871543
spellingShingle Andrea A Gossard
Keith D Lindor
Medical Management of Chronic Cholestatic Liver Diseases
Canadian Journal of Gastroenterology
title Medical Management of Chronic Cholestatic Liver Diseases
title_full Medical Management of Chronic Cholestatic Liver Diseases
title_fullStr Medical Management of Chronic Cholestatic Liver Diseases
title_full_unstemmed Medical Management of Chronic Cholestatic Liver Diseases
title_short Medical Management of Chronic Cholestatic Liver Diseases
title_sort medical management of chronic cholestatic liver diseases
url http://dx.doi.org/10.1155/2000/871543
work_keys_str_mv AT andreaagossard medicalmanagementofchroniccholestaticliverdiseases
AT keithdlindor medicalmanagementofchroniccholestaticliverdiseases