Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy
Widely known for self-renewal and multilineage differentiation, stem cells can be differentiated into all specialized tissues and cells in the body. In the past few years, a number of researchers have focused on deriving hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) as alternati...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/9919422 |
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| author | Qian Luo Honghu Li Wei Shan Cong Wei Yan Long Shuyang Cai Xiangjun Zeng Xue Li Yulin Xu Xiaoxiao Xu Yi Luo Pengxu Qian He Huang |
| author_facet | Qian Luo Honghu Li Wei Shan Cong Wei Yan Long Shuyang Cai Xiangjun Zeng Xue Li Yulin Xu Xiaoxiao Xu Yi Luo Pengxu Qian He Huang |
| author_sort | Qian Luo |
| collection | DOAJ |
| description | Widely known for self-renewal and multilineage differentiation, stem cells can be differentiated into all specialized tissues and cells in the body. In the past few years, a number of researchers have focused on deriving hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) as alternative sources for clinic. Existing findings demonstrated that it is feasible to obtain HSCs and certain mature blood lineages from PSCs, except for several issues to be addressed. This short review outlines the technologies used for hematopoietic differentiation in recent years. In addition, the therapeutic value of PSCs as a potential source of various blood cells is also discussed as well as its challenges and directions in future clinical applications. |
| format | Article |
| id | doaj-art-237c772a97cc436d96c7354b5d8014b0 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-237c772a97cc436d96c7354b5d8014b02025-02-03T07:23:59ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/99194229919422Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell TherapyQian Luo0Honghu Li1Wei Shan2Cong Wei3Yan Long4Shuyang Cai5Xiangjun Zeng6Xue Li7Yulin Xu8Xiaoxiao Xu9Yi Luo10Pengxu Qian11He Huang12BoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaBoneMarrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310012 Zhejiang, ChinaWidely known for self-renewal and multilineage differentiation, stem cells can be differentiated into all specialized tissues and cells in the body. In the past few years, a number of researchers have focused on deriving hematopoietic stem cells (HSCs) from pluripotent stem cells (PSCs) as alternative sources for clinic. Existing findings demonstrated that it is feasible to obtain HSCs and certain mature blood lineages from PSCs, except for several issues to be addressed. This short review outlines the technologies used for hematopoietic differentiation in recent years. In addition, the therapeutic value of PSCs as a potential source of various blood cells is also discussed as well as its challenges and directions in future clinical applications.http://dx.doi.org/10.1155/2021/9919422 |
| spellingShingle | Qian Luo Honghu Li Wei Shan Cong Wei Yan Long Shuyang Cai Xiangjun Zeng Xue Li Yulin Xu Xiaoxiao Xu Yi Luo Pengxu Qian He Huang Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy Stem Cells International |
| title | Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy |
| title_full | Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy |
| title_fullStr | Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy |
| title_full_unstemmed | Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy |
| title_short | Specific Blood Cells Derived from Pluripotent Stem Cells: An Emerging Field with Great Potential in Clinical Cell Therapy |
| title_sort | specific blood cells derived from pluripotent stem cells an emerging field with great potential in clinical cell therapy |
| url | http://dx.doi.org/10.1155/2021/9919422 |
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