Microwave coprocessing of modafinil with Gelucire®: Thermal and compression characteristics

Microwave coprocessing of modafinil with Gelucire®: Thermal and compression characteristics

Introduction: Modafinil, a wakefulness-promoting agent, is primarily used to treat excessive daytime sleepiness associated with narcolepsy and fatigue. As a BCS class II drug, modafinil exhibits low solubility and high permeability, with its crystalline structure significantly impacting dissolution...

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Bibliographic Details
Main Authors: Derar Omari, Assayed Sallam, Iyad Rashid, Shereen M. Assaf, Faisal Akayleh, Khaldoun A. Al-Sou′od
Format: Article
Language:English
Published: International Association of Physical Chemists (IAPC) 2025-01-01
Series:ADMET and DMPK
Subjects:
Tablet compressibility
crystallinity
molecular modeling
carbonyl oxygen of modafinil
Online Access:https://pub.iapchem.org/ojs/index.php/admet/article/view/2569
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