Torn ACL: A New Bioengineered Substitute Brought from the Laboratory to the Knee Joint
Anterior cruciate ligament (ACL) injuries occur at an annual rate of 120 000 in the USA, and many need reconstructive surgery. We report successful results at 1–13 months following implantation of bioengineered ACL (bACL) in goats. A bACL has been developed using autologous ACL cells, a collagen mat...
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| Format: | Article |
| Language: | English |
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Wiley
2004-01-01
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| Series: | Applied Bionics and Biomechanics |
| Online Access: | http://dx.doi.org/10.3233/ABB-2004-9693535 |
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| _version_ | 1832560164882874368 |
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| author | Francine Goulet Denis Rancourt Réjean Cloutier Pierrot Tremblay Anne-Marie Belzil Jean Lamontagne Marc Bouchard Julie Tremblay Louis-Mathieu Stevens Julie Labrosse Eve Langelier Marc D. McKee |
| author_facet | Francine Goulet Denis Rancourt Réjean Cloutier Pierrot Tremblay Anne-Marie Belzil Jean Lamontagne Marc Bouchard Julie Tremblay Louis-Mathieu Stevens Julie Labrosse Eve Langelier Marc D. McKee |
| author_sort | Francine Goulet |
| collection | DOAJ |
| description | Anterior cruciate ligament (ACL) injuries occur at an annual rate of 120 000 in the USA, and many need reconstructive surgery. We report successful results at 1–13 months following implantation of bioengineered ACL (bACL) in goats. A bACL has been developed using autologous ACL cells, a collagen matrix and bone plugs. The extremities of the bACL were fully integrated into the femur and tibia of the host. Vascularisation of the grafts was extensive 1 month post-surgery and improved with time. At 6 months post-grafting, histological and ultrastructural observations demonstrated a highly organised ligamentous structure, rich in type I collagen fibres and fibroblasts. At the implants' insertion sites, characteristic fibrocartilage was observed having well aligned chondrocytes and collagen fibrils. After a year, mechanical rupture of the grafts demonstrated a major gain in strength. Eventual applications of this new technology in humans include multiple uses in orthopaedic, dental and reconstructive surgeries. |
| format | Article |
| id | doaj-art-235b1d387bc14ca1bbdf0c2220721c91 |
| institution | Kabale University |
| issn | 1176-2322 1754-2103 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied Bionics and Biomechanics |
| spelling | doaj-art-235b1d387bc14ca1bbdf0c2220721c912025-02-03T01:28:11ZengWileyApplied Bionics and Biomechanics1176-23221754-21032004-01-011211512110.3233/ABB-2004-9693535Torn ACL: A New Bioengineered Substitute Brought from the Laboratory to the Knee JointFrancine Goulet0Denis Rancourt1Réjean Cloutier2Pierrot Tremblay3Anne-Marie Belzil4Jean Lamontagne5Marc Bouchard6Julie Tremblay7Louis-Mathieu Stevens8Julie Labrosse9Eve Langelier10Marc D. McKee11Laboratory of Tissue Engineering, Hôpital de l'Enfant-Jésus, Quebec, QC, CanadaDepartment of Mechanical Engineering, Laval University, Quebec, QC, CanadaLaboratory of Tissue Engineering, Hôpital de l'Enfant-Jésus, Quebec, QC, CanadaLaboratory of Tissue Engineering, Hôpital de l'Enfant-Jésus, Quebec, QC, CanadaLaboratory of Tissue Engineering, Hôpital de l'Enfant-Jésus, Quebec, QC, CanadaLaboratory of Tissue Engineering, Hôpital de l'Enfant-Jésus, Quebec, QC, CanadaLaboratory of Tissue Engineering, Hôpital de l'Enfant-Jésus, Quebec, QC, CanadaLaboratory of Tissue Engineering, Hôpital de l'Enfant-Jésus, Quebec, QC, CanadaLaboratory of Tissue Engineering, Hôpital de l'Enfant-Jésus, Quebec, QC, CanadaFaculty of Dentistry, and Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Montreal, QC, CanadaDepartment of Mechanical Engineering, Laval University, Quebec, QC, CanadaFaculty of Dentistry, and Department of Anatomy and Cell Biology, Faculty of Medicine, McGill University, Montreal, QC, CanadaAnterior cruciate ligament (ACL) injuries occur at an annual rate of 120 000 in the USA, and many need reconstructive surgery. We report successful results at 1–13 months following implantation of bioengineered ACL (bACL) in goats. A bACL has been developed using autologous ACL cells, a collagen matrix and bone plugs. The extremities of the bACL were fully integrated into the femur and tibia of the host. Vascularisation of the grafts was extensive 1 month post-surgery and improved with time. At 6 months post-grafting, histological and ultrastructural observations demonstrated a highly organised ligamentous structure, rich in type I collagen fibres and fibroblasts. At the implants' insertion sites, characteristic fibrocartilage was observed having well aligned chondrocytes and collagen fibrils. After a year, mechanical rupture of the grafts demonstrated a major gain in strength. Eventual applications of this new technology in humans include multiple uses in orthopaedic, dental and reconstructive surgeries.http://dx.doi.org/10.3233/ABB-2004-9693535 |
| spellingShingle | Francine Goulet Denis Rancourt Réjean Cloutier Pierrot Tremblay Anne-Marie Belzil Jean Lamontagne Marc Bouchard Julie Tremblay Louis-Mathieu Stevens Julie Labrosse Eve Langelier Marc D. McKee Torn ACL: A New Bioengineered Substitute Brought from the Laboratory to the Knee Joint Applied Bionics and Biomechanics |
| title | Torn ACL: A New Bioengineered Substitute Brought from the Laboratory to the Knee Joint |
| title_full | Torn ACL: A New Bioengineered Substitute Brought from the Laboratory to the Knee Joint |
| title_fullStr | Torn ACL: A New Bioengineered Substitute Brought from the Laboratory to the Knee Joint |
| title_full_unstemmed | Torn ACL: A New Bioengineered Substitute Brought from the Laboratory to the Knee Joint |
| title_short | Torn ACL: A New Bioengineered Substitute Brought from the Laboratory to the Knee Joint |
| title_sort | torn acl a new bioengineered substitute brought from the laboratory to the knee joint |
| url | http://dx.doi.org/10.3233/ABB-2004-9693535 |
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