MicroRNA Dysregulation in Cystic Fibrosis
The cystic fibrosis lung is a complex milieu comprising multiple factors that coordinate its physiology. MicroRNAs are regulatory factors involved in most biological processes and it is becoming increasingly clear that they play a key role in the development and manifestations of CF lung disease. Th...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/529642 |
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| _version_ | 1832565359724462080 |
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| author | Paul J. McKiernan Catherine M. Greene |
| author_facet | Paul J. McKiernan Catherine M. Greene |
| author_sort | Paul J. McKiernan |
| collection | DOAJ |
| description | The cystic fibrosis lung is a complex milieu comprising multiple factors that coordinate its physiology. MicroRNAs are regulatory factors involved in most biological processes and it is becoming increasingly clear that they play a key role in the development and manifestations of CF lung disease. These small noncoding RNAs act posttranscriptionally to inhibit protein production. Their involvement in the pathogenesis of CF lung disease stems from the fact that their expression is altered in vivo in the CF lung due to intrinsic and extrinsic factors; to date defective chloride ion conductance, endoplasmic reticulum stress, inflammation, and infection have been implicated in altering endogenous miRNA expression in this setting. Here, the current state-of-the-art and biological consequences of altered microRNA expression in cystic fibrosis are reviewed. |
| format | Article |
| id | doaj-art-2350ce9840a04cacaa1e2f956469c0a9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2350ce9840a04cacaa1e2f956469c0a92025-02-03T01:07:49ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/529642529642MicroRNA Dysregulation in Cystic FibrosisPaul J. McKiernan0Catherine M. Greene1Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandDepartment of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, IrelandThe cystic fibrosis lung is a complex milieu comprising multiple factors that coordinate its physiology. MicroRNAs are regulatory factors involved in most biological processes and it is becoming increasingly clear that they play a key role in the development and manifestations of CF lung disease. These small noncoding RNAs act posttranscriptionally to inhibit protein production. Their involvement in the pathogenesis of CF lung disease stems from the fact that their expression is altered in vivo in the CF lung due to intrinsic and extrinsic factors; to date defective chloride ion conductance, endoplasmic reticulum stress, inflammation, and infection have been implicated in altering endogenous miRNA expression in this setting. Here, the current state-of-the-art and biological consequences of altered microRNA expression in cystic fibrosis are reviewed.http://dx.doi.org/10.1155/2015/529642 |
| spellingShingle | Paul J. McKiernan Catherine M. Greene MicroRNA Dysregulation in Cystic Fibrosis Mediators of Inflammation |
| title | MicroRNA Dysregulation in Cystic Fibrosis |
| title_full | MicroRNA Dysregulation in Cystic Fibrosis |
| title_fullStr | MicroRNA Dysregulation in Cystic Fibrosis |
| title_full_unstemmed | MicroRNA Dysregulation in Cystic Fibrosis |
| title_short | MicroRNA Dysregulation in Cystic Fibrosis |
| title_sort | microrna dysregulation in cystic fibrosis |
| url | http://dx.doi.org/10.1155/2015/529642 |
| work_keys_str_mv | AT pauljmckiernan micrornadysregulationincysticfibrosis AT catherinemgreene micrornadysregulationincysticfibrosis |