Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes
Abstract We assessed temporal changes of PFAS and associations with T2DM over a period of 30 years in a nested case–control study with repeated measurements. Logistic regression was used to assess associations between 11 PFAS and T2DM at five time-points in 116 cases and 139 controls (3 pre- and 2 p...
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Nature Portfolio
2025-07-01
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| author | Vivian Berg Dolley D. Charles Sandra Huber Therese H. Nøst Torkjel M. Sandanger Maria Averina Ingvar A. Bergdahl Mia M. Nilsen Tom Wilsgaard Charlotta Rylander |
| author_facet | Vivian Berg Dolley D. Charles Sandra Huber Therese H. Nøst Torkjel M. Sandanger Maria Averina Ingvar A. Bergdahl Mia M. Nilsen Tom Wilsgaard Charlotta Rylander |
| author_sort | Vivian Berg |
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| description | Abstract We assessed temporal changes of PFAS and associations with T2DM over a period of 30 years in a nested case–control study with repeated measurements. Logistic regression was used to assess associations between 11 PFAS and T2DM at five time-points in 116 cases and 139 controls (3 pre- and 2 post-diagnostic time-points in cases). Mixed linear models were applied to assess if changes in PFAS were related to T2DM status. In the pre-diagnostic time-point T3 (2001), future cases had higher concentrations of PFHpA, PFNA, PFHxS and PFHpS compared to controls. In the post-diagnostic time point T5 (2015/16), PFNA and PFOS were higher in prevalent cases. PFHxS and PFHpS were positively associated with future T2DM at the pre-diagnostic time-point T3, whereas PFTrDA were inversely associated with future T2DM at T1 (1986/87) and prevalent T2DM at T4 (2007/8). Temporal changes in PFAS across the study period showed that cases experienced a greater increase in pre-diagnostic concentrations of PFHpA, PFTrDA, PFHxS and PFOSA, as well as a larger post-diagnostic decrease in PFOSA, compared to controls. This study is the first to show that temporal changes in PFAS are associated with T2DM status for certain PFAS, and associations between PFAS and T2DM vary according to sample year. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-234f2eb9fe044bf3933ddcf63b1b9e292025-08-20T04:01:24ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-05422-1Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetesVivian Berg0Dolley D. Charles1Sandra Huber2Therese H. Nøst3Torkjel M. Sandanger4Maria Averina5Ingvar A. Bergdahl6Mia M. Nilsen7Tom Wilsgaard8Charlotta Rylander9Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of NorwayDepartment of Community Medicine, Faculty of Health Sciences, UiT - The Arctic University of NorwayDepartment of Laboratory Medicine, University Hospital of North-NorwayDepartment of Community Medicine, Faculty of Health Sciences, UiT - The Arctic University of NorwayDepartment of Community Medicine, Faculty of Health Sciences, UiT - The Arctic University of NorwayDepartment of Laboratory Medicine, University Hospital of North-NorwayDepartment of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå UniversityDepartment of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of NorwayDepartment of Community Medicine, Faculty of Health Sciences, UiT - The Arctic University of NorwayDepartment of Community Medicine, Faculty of Health Sciences, UiT - The Arctic University of NorwayAbstract We assessed temporal changes of PFAS and associations with T2DM over a period of 30 years in a nested case–control study with repeated measurements. Logistic regression was used to assess associations between 11 PFAS and T2DM at five time-points in 116 cases and 139 controls (3 pre- and 2 post-diagnostic time-points in cases). Mixed linear models were applied to assess if changes in PFAS were related to T2DM status. In the pre-diagnostic time-point T3 (2001), future cases had higher concentrations of PFHpA, PFNA, PFHxS and PFHpS compared to controls. In the post-diagnostic time point T5 (2015/16), PFNA and PFOS were higher in prevalent cases. PFHxS and PFHpS were positively associated with future T2DM at the pre-diagnostic time-point T3, whereas PFTrDA were inversely associated with future T2DM at T1 (1986/87) and prevalent T2DM at T4 (2007/8). Temporal changes in PFAS across the study period showed that cases experienced a greater increase in pre-diagnostic concentrations of PFHpA, PFTrDA, PFHxS and PFOSA, as well as a larger post-diagnostic decrease in PFOSA, compared to controls. This study is the first to show that temporal changes in PFAS are associated with T2DM status for certain PFAS, and associations between PFAS and T2DM vary according to sample year.https://doi.org/10.1038/s41598-025-05422-1Per- and polyfluoroalkyl substancesType 2 diabetes mellitusTemporal changeProspective case–control studyRepeated measurementsPre- and post-diagnostic associations |
| spellingShingle | Vivian Berg Dolley D. Charles Sandra Huber Therese H. Nøst Torkjel M. Sandanger Maria Averina Ingvar A. Bergdahl Mia M. Nilsen Tom Wilsgaard Charlotta Rylander Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes Scientific Reports Per- and polyfluoroalkyl substances Type 2 diabetes mellitus Temporal change Prospective case–control study Repeated measurements Pre- and post-diagnostic associations |
| title | Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes |
| title_full | Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes |
| title_fullStr | Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes |
| title_full_unstemmed | Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes |
| title_short | Temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes |
| title_sort | temporal changes in per and polyfluoroalkyl substances and their associations with type 2 diabetes |
| topic | Per- and polyfluoroalkyl substances Type 2 diabetes mellitus Temporal change Prospective case–control study Repeated measurements Pre- and post-diagnostic associations |
| url | https://doi.org/10.1038/s41598-025-05422-1 |
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