Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study
Background and Objectives: Colorectal cancer is a major contributor to global cancer morbidity and mortality. Surgical resection remains the cornerstone of treatment, but postoperative complications can significantly affect patient outcomes. Identifying factors that influence postoperative morbidity...
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2025-01-01
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| author | Lucian Flavius Herlo Ioana Golu Alexandra Herlo Claudia Raluca Balasa Virzob Ionescu Alin Stela Iurciuc Ionut Eduard Iordache Luana Alexandrescu Doina Ecaterina Tofolean Raluca Dumache |
| author_facet | Lucian Flavius Herlo Ioana Golu Alexandra Herlo Claudia Raluca Balasa Virzob Ionescu Alin Stela Iurciuc Ionut Eduard Iordache Luana Alexandrescu Doina Ecaterina Tofolean Raluca Dumache |
| author_sort | Lucian Flavius Herlo |
| collection | DOAJ |
| description | Background and Objectives: Colorectal cancer is a major contributor to global cancer morbidity and mortality. Surgical resection remains the cornerstone of treatment, but postoperative complications can significantly affect patient outcomes. Identifying factors that influence postoperative morbidity and mortality is crucial for optimizing patient care. This study aims to evaluate the impact of preoperative, intraoperative, and postoperative factors on surgical outcomes in patients with colorectal cancer. Methods: A retrospective cohort study was conducted on 688 patients who underwent colorectal cancer surgery within a 10-year period. Data collected included demographic information, comorbidities, laboratory values, surgical details, and postoperative outcomes. Statistical analyses were performed using chi-square tests for categorical variables and t-tests for continuous variables. Multivariate logistic regression was used to identify independent predictors of postoperative complications and mortality. Results: Postoperative complications occurred in 28.5% of patients, and the 30-day mortality rate was 5.2%. Preoperative factors such as elevated C-reactive protein (CRP) levels (<i>p</i> < 0.001), low albumin levels (<i>p</i> = 0.003), a high American Society of Anesthesiologists (ASA) score (<i>p</i> < 0.001), and presence of comorbidities like diabetes and hypertension (<i>p</i> = 0.005) were significantly associated with increased postoperative complications. Intraoperative factors such as blood loss greater than 500 mL (<i>p</i> < 0.001) and longer operative time (<i>p</i> = 0.021) were also significant predictors of adverse outcomes. Multivariate analysis identified elevated CRP (OR 2.1, 95% CI 1.5–2.9), low albumin (OR 1.8, 95% CI 1.3–2.5), and blood loss > 500 mL (OR 2.4, 95% CI 1.7–3.4) as independent predictors of postoperative complications. Conclusions: Preoperative inflammatory markers, nutritional status, ASA score, comorbidities, and intraoperative factors like blood loss significantly influence postoperative outcomes in colorectal cancer surgery. Recognizing these risk factors allows for better preoperative optimization and surgical planning, potentially reducing postoperative morbidity and mortality. |
| format | Article |
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| institution | Kabale University |
| issn | 2079-9721 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-234792482df14734b8427689b73fd8bb2025-01-24T13:29:16ZengMDPI AGDiseases2079-97212025-01-011311610.3390/diseases13010016Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective StudyLucian Flavius Herlo0Ioana Golu1Alexandra Herlo2Claudia Raluca Balasa Virzob3Ionescu Alin4Stela Iurciuc5Ionut Eduard Iordache6Luana Alexandrescu7Doina Ecaterina Tofolean8Raluca Dumache9Doctoral School, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Internal Medicine II, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment XIII, Discipline of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, RomaniaDepartment of Clinic Nursing, “Victor Babes” University of Medicine and Pharmacy Timisoara, 2 Eftimie Murgu Square, 300041 Timisoara, RomaniaDepartment XVI, Discipline of Family Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaCardiology Department, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of General Surgery, Faculty of Medicine and Pharmacy Constanta, Ovidius University, 900470 Constanta, RomaniaDepartment of Gastroenterology, Faculty of Medicine and Pharmacy Constanta, Ovidius University, 900470 Constanta, RomaniaDepartment of Gastroenterology, Faculty of Medicine and Pharmacy Constanta, Ovidius University, 900470 Constanta, RomaniaDepartment of Forensic Medicine, Bioethics, Medical Ethics and Medical Law, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaBackground and Objectives: Colorectal cancer is a major contributor to global cancer morbidity and mortality. Surgical resection remains the cornerstone of treatment, but postoperative complications can significantly affect patient outcomes. Identifying factors that influence postoperative morbidity and mortality is crucial for optimizing patient care. This study aims to evaluate the impact of preoperative, intraoperative, and postoperative factors on surgical outcomes in patients with colorectal cancer. Methods: A retrospective cohort study was conducted on 688 patients who underwent colorectal cancer surgery within a 10-year period. Data collected included demographic information, comorbidities, laboratory values, surgical details, and postoperative outcomes. Statistical analyses were performed using chi-square tests for categorical variables and t-tests for continuous variables. Multivariate logistic regression was used to identify independent predictors of postoperative complications and mortality. Results: Postoperative complications occurred in 28.5% of patients, and the 30-day mortality rate was 5.2%. Preoperative factors such as elevated C-reactive protein (CRP) levels (<i>p</i> < 0.001), low albumin levels (<i>p</i> = 0.003), a high American Society of Anesthesiologists (ASA) score (<i>p</i> < 0.001), and presence of comorbidities like diabetes and hypertension (<i>p</i> = 0.005) were significantly associated with increased postoperative complications. Intraoperative factors such as blood loss greater than 500 mL (<i>p</i> < 0.001) and longer operative time (<i>p</i> = 0.021) were also significant predictors of adverse outcomes. Multivariate analysis identified elevated CRP (OR 2.1, 95% CI 1.5–2.9), low albumin (OR 1.8, 95% CI 1.3–2.5), and blood loss > 500 mL (OR 2.4, 95% CI 1.7–3.4) as independent predictors of postoperative complications. Conclusions: Preoperative inflammatory markers, nutritional status, ASA score, comorbidities, and intraoperative factors like blood loss significantly influence postoperative outcomes in colorectal cancer surgery. Recognizing these risk factors allows for better preoperative optimization and surgical planning, potentially reducing postoperative morbidity and mortality.https://www.mdpi.com/2079-9721/13/1/16colorectal cancerpostoperative complicationspreoperative factorsintraoperative factorssurgical outcomesCRP |
| spellingShingle | Lucian Flavius Herlo Ioana Golu Alexandra Herlo Claudia Raluca Balasa Virzob Ionescu Alin Stela Iurciuc Ionut Eduard Iordache Luana Alexandrescu Doina Ecaterina Tofolean Raluca Dumache Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study Diseases colorectal cancer postoperative complications preoperative factors intraoperative factors surgical outcomes CRP |
| title | Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study |
| title_full | Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study |
| title_fullStr | Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study |
| title_full_unstemmed | Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study |
| title_short | Impact of Preoperative and Intraoperative Factors on Postoperative Outcomes in Patients with Colorectal Cancer: A 10-Year Retrospective Study |
| title_sort | impact of preoperative and intraoperative factors on postoperative outcomes in patients with colorectal cancer a 10 year retrospective study |
| topic | colorectal cancer postoperative complications preoperative factors intraoperative factors surgical outcomes CRP |
| url | https://www.mdpi.com/2079-9721/13/1/16 |
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