Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer
Endometrial cancer (EC), one of the most common gynecologic malignancies worldwide, poses a significant burden particularly among young women, with poor treatment outcomes and prognosis for advanced and recurrent patients. Epigenetic changes, encompassing DNA methylation, are involved in the occurre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1455255/full |
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| author | Minzhen Li Minzhen Li Zhili Xia Ruiyu Wang Ruiyu Wang Mingrong Xi Mingrong Xi Minmin Hou Minmin Hou |
| author_facet | Minzhen Li Minzhen Li Zhili Xia Ruiyu Wang Ruiyu Wang Mingrong Xi Mingrong Xi Minmin Hou Minmin Hou |
| author_sort | Minzhen Li |
| collection | DOAJ |
| description | Endometrial cancer (EC), one of the most common gynecologic malignancies worldwide, poses a significant burden particularly among young women, with poor treatment outcomes and prognosis for advanced and recurrent patients. Epigenetic changes, encompassing DNA methylation, are involved in the occurrence and progression of tumors and hold promise as effective tools for screening, early diagnosis, treatment strategy, efficacy evaluation, and prognosis analysis. This review provides a comprehensive summary of DNA methylation-based early diagnostic biomarkers in EC, with a focus on recent valuable research findings published in the past two years. The discussion is organized according to sample sources, including cervical scraping, vaginal fluid, urine, blood, and tissue. Additionally, we outline the role of DNA methylation in EC risk assessment, such as carcinogenesis risk, feasibility of fertility preservation approaches, and overall prognosis, aiming to provide personalized treatment decisions for patients. Finally, we review researches on DNA methylation in resistance to first-line treatment of EC and the development of new drugs, and envision the future applications of DNA methylation in EC. |
| format | Article |
| id | doaj-art-2345d241b0bc434286f734fd3c59bf8a |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-2345d241b0bc434286f734fd3c59bf8a2025-01-20T05:23:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14552551455255Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancerMinzhen Li0Minzhen Li1Zhili Xia2Ruiyu Wang3Ruiyu Wang4Mingrong Xi5Mingrong Xi6Minmin Hou7Minmin Hou8Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaThe First Clinical Medical College, Lanzhou University, Lanzhou, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaDepartment of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, ChinaEndometrial cancer (EC), one of the most common gynecologic malignancies worldwide, poses a significant burden particularly among young women, with poor treatment outcomes and prognosis for advanced and recurrent patients. Epigenetic changes, encompassing DNA methylation, are involved in the occurrence and progression of tumors and hold promise as effective tools for screening, early diagnosis, treatment strategy, efficacy evaluation, and prognosis analysis. This review provides a comprehensive summary of DNA methylation-based early diagnostic biomarkers in EC, with a focus on recent valuable research findings published in the past two years. The discussion is organized according to sample sources, including cervical scraping, vaginal fluid, urine, blood, and tissue. Additionally, we outline the role of DNA methylation in EC risk assessment, such as carcinogenesis risk, feasibility of fertility preservation approaches, and overall prognosis, aiming to provide personalized treatment decisions for patients. Finally, we review researches on DNA methylation in resistance to first-line treatment of EC and the development of new drugs, and envision the future applications of DNA methylation in EC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1455255/fullDNA methylationendometrial cancerearly diagnostic biomarkerrisk assessmentfertility preservationprognosis |
| spellingShingle | Minzhen Li Minzhen Li Zhili Xia Ruiyu Wang Ruiyu Wang Mingrong Xi Mingrong Xi Minmin Hou Minmin Hou Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer Frontiers in Oncology DNA methylation endometrial cancer early diagnostic biomarker risk assessment fertility preservation prognosis |
| title | Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer |
| title_full | Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer |
| title_fullStr | Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer |
| title_full_unstemmed | Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer |
| title_short | Unveiling DNA methylation: early diagnosis, risk assessment, and therapy for endometrial cancer |
| title_sort | unveiling dna methylation early diagnosis risk assessment and therapy for endometrial cancer |
| topic | DNA methylation endometrial cancer early diagnostic biomarker risk assessment fertility preservation prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1455255/full |
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