Long-term outcomes of corneal transplantation: a review of 8,378 patients
Abstract Purpose To analyze the outcomes of corneal transplantation procedures over a 13-year period at Farabi Eye Hospital, Tehran, Iran, to identify trends and determinants influencing the frequency and success of primary and re-transplantations. Methods Utilizing a comprehensive dataset from the...
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BMC
2025-01-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03826-7 |
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| author | Mohammad Nasser Hashemian Mohammad Javad Zia Masoud Khorrami-Nejad Qaysser Sattar Abed Hesam Hashemian |
| author_facet | Mohammad Nasser Hashemian Mohammad Javad Zia Masoud Khorrami-Nejad Qaysser Sattar Abed Hesam Hashemian |
| author_sort | Mohammad Nasser Hashemian |
| collection | DOAJ |
| description | Abstract Purpose To analyze the outcomes of corneal transplantation procedures over a 13-year period at Farabi Eye Hospital, Tehran, Iran, to identify trends and determinants influencing the frequency and success of primary and re-transplantations. Methods Utilizing a comprehensive dataset from the hospital’s Hospital Information System, the study reviewed the records of 8,378 patients who underwent corneal transplants between 2009 and 2022. This analysis included demographic information, surgical details, and follow-up data. Statistical methods were applied to assess the impact of variables such as age, gender, surgeon experience, and surgical techniques on the likelihood of re-transplantation. Results Of the 8,378 transplants, 7,660 (91.4%) were primary procedures while 718 (8.6%) involved re-transplantation. The most common primary transplant was penetrating keratoplasty (PKP, 50.3%), followed by Descemet’s stripping endothelial keratoplasty (DSAEK, 29.3%), and deep anterior lamellar keratoplasty (DALK, 18.5%). Analysis revealed no significant association between re-transplantation rates and patient gender or nationality. Older recipient age correlates with higher re-transplantation rates, likely due to reduced regenerative capacity and increased comorbidities in older patients. Pre-transplant comorbidities (e.g., keratoconus, ulcers), concurrent surgeries (e.g., vitrectomy), and prior procedures (e.g., glaucoma surgeries, IOL implantation) significantly increase re-transplantation risk, likely due to additional ocular stress and inflammation. Conclusion The study highlights the importance of patient age, surgeon experience, and the choice of surgical technique in the success rates of corneal transplants. These factors are crucial for optimizing patient outcomes and minimizing the necessity for re-transplantations. |
| format | Article |
| id | doaj-art-233dc343f1e44e65b6f7c1f510e28243 |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-233dc343f1e44e65b6f7c1f510e282432025-01-26T12:21:11ZengBMCBMC Ophthalmology1471-24152025-01-012511810.1186/s12886-024-03826-7Long-term outcomes of corneal transplantation: a review of 8,378 patientsMohammad Nasser Hashemian0Mohammad Javad Zia1Masoud Khorrami-Nejad2Qaysser Sattar Abed3Hesam Hashemian4Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesTranslational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesSchool of Rehabilitation, Tehran University of Medical SciencesSchool of Rehabilitation, Tehran University of Medical SciencesTranslational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical SciencesAbstract Purpose To analyze the outcomes of corneal transplantation procedures over a 13-year period at Farabi Eye Hospital, Tehran, Iran, to identify trends and determinants influencing the frequency and success of primary and re-transplantations. Methods Utilizing a comprehensive dataset from the hospital’s Hospital Information System, the study reviewed the records of 8,378 patients who underwent corneal transplants between 2009 and 2022. This analysis included demographic information, surgical details, and follow-up data. Statistical methods were applied to assess the impact of variables such as age, gender, surgeon experience, and surgical techniques on the likelihood of re-transplantation. Results Of the 8,378 transplants, 7,660 (91.4%) were primary procedures while 718 (8.6%) involved re-transplantation. The most common primary transplant was penetrating keratoplasty (PKP, 50.3%), followed by Descemet’s stripping endothelial keratoplasty (DSAEK, 29.3%), and deep anterior lamellar keratoplasty (DALK, 18.5%). Analysis revealed no significant association between re-transplantation rates and patient gender or nationality. Older recipient age correlates with higher re-transplantation rates, likely due to reduced regenerative capacity and increased comorbidities in older patients. Pre-transplant comorbidities (e.g., keratoconus, ulcers), concurrent surgeries (e.g., vitrectomy), and prior procedures (e.g., glaucoma surgeries, IOL implantation) significantly increase re-transplantation risk, likely due to additional ocular stress and inflammation. Conclusion The study highlights the importance of patient age, surgeon experience, and the choice of surgical technique in the success rates of corneal transplants. These factors are crucial for optimizing patient outcomes and minimizing the necessity for re-transplantations.https://doi.org/10.1186/s12886-024-03826-7Corneal transplantationRe-transplantation ratesSurgical outcomesPenetrating keratoplasty (PKP)Retrospective analysis |
| spellingShingle | Mohammad Nasser Hashemian Mohammad Javad Zia Masoud Khorrami-Nejad Qaysser Sattar Abed Hesam Hashemian Long-term outcomes of corneal transplantation: a review of 8,378 patients BMC Ophthalmology Corneal transplantation Re-transplantation rates Surgical outcomes Penetrating keratoplasty (PKP) Retrospective analysis |
| title | Long-term outcomes of corneal transplantation: a review of 8,378 patients |
| title_full | Long-term outcomes of corneal transplantation: a review of 8,378 patients |
| title_fullStr | Long-term outcomes of corneal transplantation: a review of 8,378 patients |
| title_full_unstemmed | Long-term outcomes of corneal transplantation: a review of 8,378 patients |
| title_short | Long-term outcomes of corneal transplantation: a review of 8,378 patients |
| title_sort | long term outcomes of corneal transplantation a review of 8 378 patients |
| topic | Corneal transplantation Re-transplantation rates Surgical outcomes Penetrating keratoplasty (PKP) Retrospective analysis |
| url | https://doi.org/10.1186/s12886-024-03826-7 |
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