Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo

Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo

Adipose mesenchymal stem cells (ASCs) are considered as the promising seed cells for bone regeneration. However, the lower osteogenic differentiation capacity limits its therapeutic efficacy. Identification of the key molecules governing the differences between ASCs and BMSCs would shed light on man...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xiangwei Liu, Naiwen Tan, Yuchao Zhou, Xueying Zhou, Hui Chen, Hongbo Wei, Ji Chen, Xiaoru Xu, Sijia Zhang, Guodong Yang, Yingliang Song
Format:	Article
Language:	English
Published:	Wiley 2016-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2016/2545214
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Local Application of Semaphorin 3A Combined with Adipose-Derived Stem Cell Sheet and Anorganic Bovine Bone Granules Enhances Bone Regeneration in Type 2 Diabetes Mellitus Rats
by: Xiaoru Xu, et al.
Published: (2019-01-01)

Semaphorin3B Promotes Proliferation and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in a High-Glucose Microenvironment
by: Quan Xing, et al.
Published: (2021-01-01)

Hypermethylation in Calca Promoter Inhibited ASC Osteogenic Differentiation in Rats with Type 2 Diabetic Mellitus
by: Lei Wang, et al.
Published: (2020-01-01)

Dual functional hydrogel of osteoclastic-inhibition and osteogenic-stimulation for osteoporotic bone defect regeneration
by: Lei Yu, et al.
Published: (2025-04-01)

Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress
by: Chikako Sumi, et al.
Published: (2018-01-01)

Semaphorin-4D signaling in recruiting dental stem cells for vascular stabilization
by: Lili Zhang, et al.
Published: (2025-01-01)

HDL Subclass Distribution Shifts with Increasing Central Adiposity
by: Nicholas J. Woudberg, et al.
Published: (2019-01-01)

An In Vitro and In Vivo Comparison of Osteogenic Differentiation of Human Mesenchymal Stromal/Stem Cells
by: Jamie Mollentze, et al.
Published: (2021-01-01)

Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues
by: Christina D. Drenberg, et al.
Published: (2009-01-01)

A Comparative Evaluation of the Mechanical Properties of Two Calcium Phosphate/Collagen Composite Materials and Their Osteogenic Effects on Adipose-Derived Stem Cells
by: Qing Li, et al.
Published: (2016-01-01)

Phenotypic stability of spring bread wheat regenerant lines
by: V. Yu. Stupko, et al.
Published: (2023-04-01)

Effects of Naringin on Proliferation and Osteogenic Differentiation of Human Periodontal Ligament Stem Cells In Vitro and In Vivo
by: Lihua Yin, et al.
Published: (2015-01-01)

The Effect of Clopidogrel and Ticagrelor on Human Adipose Mesenchymal Stem Cell Osteogenic Differentiation Potential: In Vitro Comparative Study
by: Sally S. Mohamed, et al.
Published: (2024-01-01)

Deciphering the Transcriptional Metabolic Profile of Adipose-Derived Stem Cells During Osteogenic Differentiation and Epigenetic Drug Treatment
by: Giulia Gerini, et al.
Published: (2025-01-01)

Abnormal methylation of Mill1 gene regulates osteogenic differentiation involved in various phenotypes of skeletal fluorosis in rats and methionine intervention
by: Niannian Chen, et al.
Published: (2025-01-01)

Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A
by: Séverine Lecourt, et al.
Published: (2012-01-01)

Enhanced Osteogenic and Vasculogenic Differentiation Potential of Human Adipose Stem Cells on Biphasic Calcium Phosphate Scaffolds in Fibrin Gels
by: Fransisca A. S. van Esterik, et al.
Published: (2016-01-01)

Adipose Stem Cell-Based Clinical Strategy for Neural Regeneration: A Review of Current Opinion
by: Yu-hao Wang, et al.
Published: (2019-01-01)

miR-129-5p Promotes Osteogenic Differentiation of BMSCs and Bone Regeneration via Repressing Dkk3
by: Changming Zhao, et al.
Published: (2021-01-01)

Polycaprolactone for Hard Tissue Regeneration: Scaffold Design and In Vivo Implications
by: Fernanda Ramírez-Ruiz, et al.
Published: (2025-01-01)

Marrow Adipose Tissue: Its Origin, Function, and Regulation in Bone Remodeling and Regeneration
by: Qiwen Li, et al.
Published: (2018-01-01)

Exercise reduced the formation of new adipocytes in the adipose tissue of mice in vivo.
by: Timothy D Allerton, et al.
Published: (2021-01-01)

Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages
by: Laura Hyväri, et al.
Published: (2018-01-01)

The Angiogenic Potential of DPSCs and SCAPs in an In Vivo Model of Dental Pulp Regeneration
by: Petra Hilkens, et al.
Published: (2017-01-01)

Cytokines TNF-α, IL-6, IL-17F, and IL-4 Differentially Affect Osteogenic Differentiation of Human Adipose Stem Cells
by: Angela P. Bastidas-Coral, et al.
Published: (2016-01-01)

The Effect of Blood-Derived Products on the Chondrogenic and Osteogenic Differentiation Potential of Adipose-Derived Mesenchymal Stem Cells Originated from Three Different Locations
by: Markus Neubauer, et al.
Published: (2019-01-01)

Regional adipose distribution and metabolically unhealthy phenotype in Chinese adults: evidence from China National Health Survey
by: Binbin Lin, et al.
Published: (2025-01-01)

Reevolution of Tissue Regeneration: From Recent Advances in Adipose Stem Cells to Novel Therapeutic Approaches
by: Francesco De Francesco, et al.
Published: (2021-01-01)

In Vivo Experiments with Dental Pulp Stem Cells for Pulp-Dentin Complex Regeneration
by: Sunil Kim, et al.
Published: (2015-01-01)

Plant Regeneration and Cellular Behaviour Studies in Celosia cristata Grown In Vivo and In Vitro
by: Rosna Mat Taha, et al.
Published: (2012-01-01)

Subcutaneous Adipose Tissue from Obese and Lean Adults Does Not Release Hepcidin In Vivo
by: Lisa Tussing-Humphreys, et al.
Published: (2011-01-01)

Adipose-Derived Mesenchymal Stem Cells Promote M2 Macrophage Phenotype through Exosomes
by: June Seok Heo, et al.
Published: (2019-01-01)

The Gingiva from the Tissue Surrounding the Bone to the Tissue Regenerating the Bone: A Systematic Review of the Osteogenic Capacity of Gingival Mesenchymal Stem Cells in Preclinical Studies
by: Gamilah Al-Qadhi, et al.
Published: (2021-01-01)

Semaphorin 3A Increases FAK Phosphorylation at Focal Adhesions to Modulate MDA-MB-231 Cell Migration and Spreading on Different Substratum Concentrations
by: Scott Gehler, et al.
Published: (2017-01-01)

The shift from new build to regeneration. Can the New Bauhaus transform architecture and design to meet global challenges?
by: David Ness
Published: (2021-06-01)

Dose-Dependent Differential Effect of Neurotrophic Factors on In Vitro and In Vivo Regeneration of Motor and Sensory Neurons
by: Daniel Santos, et al.
Published: (2016-01-01)

Advancing ex vivo functional whole-organ prostate gland model for regeneration and drug screening
by: Karthikeyan Subbiahanadar Chelladurai, et al.
Published: (2025-01-01)

Electrospun Gelatin/β-TCP Composite Nanofibers Enhance Osteogenic Differentiation of BMSCs and In Vivo Bone Formation by Activating Ca2+-Sensing Receptor Signaling
by: Xuehui Zhang, et al.
Published: (2015-01-01)

Expression of osteogenic proteins in kidneys of cats with nephrocalcinosis
by: Nuttha Hengtrakul, et al.
Published: (2025-01-01)

Adipose-Derived Stem Cell Transplantation Attenuates Inflammation and Promotes Liver Regeneration after Ischemia-Reperfusion and Hemihepatectomy in Swine
by: Zhihui Jiao, et al.
Published: (2019-01-01)