Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time

Multiple trace theory (MTT) predicts that hippocampal memory traces expand and strengthen as a function of repeated memory retrievals. We tested this hypothesis utilizing fMRI, comparing the effect of memory retrieval versus the mere passage of time on hippocampal activation. While undergoing fMRI s...

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Main Authors: Lynn Nadel, Jenna Campbell, Lee Ryan
Format: Article
Language:English
Published: Wiley 2007-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2007/90472
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author Lynn Nadel
Jenna Campbell
Lee Ryan
author_facet Lynn Nadel
Jenna Campbell
Lee Ryan
author_sort Lynn Nadel
collection DOAJ
description Multiple trace theory (MTT) predicts that hippocampal memory traces expand and strengthen as a function of repeated memory retrievals. We tested this hypothesis utilizing fMRI, comparing the effect of memory retrieval versus the mere passage of time on hippocampal activation. While undergoing fMRI scanning, participants retrieved remote autobiographical memories that had been previously retrieved either one month earlier, two days earlier, or multiple times during the preceding month. Behavioral analyses revealed that the number and consistency of memory details retrieved increased with multiple retrievals but not with the passage of time. While all three retrieval conditions activated a similar set of brain regions normally associated with autobiographical memory retrieval including medial temporal lobe structures, hippocampal activation did not change as a function of either multiple retrievals or the passage of time. However, activation in other brain regions, including the precuneus, lateral prefrontal cortex, parietal cortex, lateral temporal lobe, and perirhinal cortex increased after multiple retrievals, but was not influenced by the passage of time. These results have important implications for existing theories of long-term memory consolidation.
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spelling doaj-art-2319dad4530e42149f1c3cfe02f80f4c2025-02-03T01:20:23ZengWileyNeural Plasticity2090-59041687-54432007-01-01200710.1155/2007/9047290472Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of TimeLynn Nadel0Jenna Campbell1Lee Ryan2Department of Psychology, University of Arizona, Tucson, AZ 85721, USADepartment of Psychology, University of Arizona, Tucson, AZ 85721, USADepartment of Psychology, University of Arizona, Tucson, AZ 85721, USAMultiple trace theory (MTT) predicts that hippocampal memory traces expand and strengthen as a function of repeated memory retrievals. We tested this hypothesis utilizing fMRI, comparing the effect of memory retrieval versus the mere passage of time on hippocampal activation. While undergoing fMRI scanning, participants retrieved remote autobiographical memories that had been previously retrieved either one month earlier, two days earlier, or multiple times during the preceding month. Behavioral analyses revealed that the number and consistency of memory details retrieved increased with multiple retrievals but not with the passage of time. While all three retrieval conditions activated a similar set of brain regions normally associated with autobiographical memory retrieval including medial temporal lobe structures, hippocampal activation did not change as a function of either multiple retrievals or the passage of time. However, activation in other brain regions, including the precuneus, lateral prefrontal cortex, parietal cortex, lateral temporal lobe, and perirhinal cortex increased after multiple retrievals, but was not influenced by the passage of time. These results have important implications for existing theories of long-term memory consolidation.http://dx.doi.org/10.1155/2007/90472
spellingShingle Lynn Nadel
Jenna Campbell
Lee Ryan
Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time
Neural Plasticity
title Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time
title_full Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time
title_fullStr Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time
title_full_unstemmed Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time
title_short Autobiographical Memory Retrieval and Hippocampal Activation as a Function of Repetition and the Passage of Time
title_sort autobiographical memory retrieval and hippocampal activation as a function of repetition and the passage of time
url http://dx.doi.org/10.1155/2007/90472
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