Evaluation of the deleted in malignant brain tumor 1 protein expression and DNA methylation profile in rheumatoid arthritis patients
Background: Rheumatoid arthritis (RA) is a chronic, autoimmune disease that progressively leads to joint destruction and functional disability which eventually affects the quality of life of the people suffering from it. Deleted in malignant brain tumor 1 (DMBT1) role has been explored in progressio...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=1;spage=68;epage=73;aulast=Choudhury |
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| _version_ | 1832563477450850304 |
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| author | Khushboo Choudhury Monika Gandhi Uma Kumar Sayan Chatterjee Ram Singh Purty |
| author_facet | Khushboo Choudhury Monika Gandhi Uma Kumar Sayan Chatterjee Ram Singh Purty |
| author_sort | Khushboo Choudhury |
| collection | DOAJ |
| description | Background: Rheumatoid arthritis (RA) is a chronic, autoimmune disease that progressively leads to joint destruction and functional disability which eventually affects the quality of life of the people suffering from it. Deleted in malignant brain tumor 1 (DMBT1) role has been explored in progression of Sjögren's syndrome (SS) and other autoimmune diseases, whereas it has yet to be reported in RA. In this study, we have analyzed and evaluated the expression of DMBT1 protein and the dmbt1 genes' methylation status in healthy volunteers, RA, and SS patients.
Methods: In the present investigation, the case–control study of 25 healthy volunteers and 17 RA- and 10 SS-confirmed patients was performed.
Results: It was observed that the concentration of DMBT1 protein in saliva decreases in both the disease conditions compared to healthy volunteers, while methylation status of dmbt1 gene was low in both patient cohorts in comparison to the healthy controls.
Conclusion: Results obtained from this study indicate that DMBT1 protein has the potential to qualify as a specific salivary biomarker as identified in RA and SS patients. DMBT1 protein can therefore be explored further as a noninvasive tool for diagnosis and prognosis. |
| format | Article |
| id | doaj-art-2319b5a785ed4829a8846506588c7872 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-2319b5a785ed4829a8846506588c78722025-02-03T01:13:26ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012023-01-01181687310.4103/injr.injr_181_21Evaluation of the deleted in malignant brain tumor 1 protein expression and DNA methylation profile in rheumatoid arthritis patientsKhushboo ChoudhuryMonika GandhiUma KumarSayan ChatterjeeRam Singh PurtyBackground: Rheumatoid arthritis (RA) is a chronic, autoimmune disease that progressively leads to joint destruction and functional disability which eventually affects the quality of life of the people suffering from it. Deleted in malignant brain tumor 1 (DMBT1) role has been explored in progression of Sjögren's syndrome (SS) and other autoimmune diseases, whereas it has yet to be reported in RA. In this study, we have analyzed and evaluated the expression of DMBT1 protein and the dmbt1 genes' methylation status in healthy volunteers, RA, and SS patients. Methods: In the present investigation, the case–control study of 25 healthy volunteers and 17 RA- and 10 SS-confirmed patients was performed. Results: It was observed that the concentration of DMBT1 protein in saliva decreases in both the disease conditions compared to healthy volunteers, while methylation status of dmbt1 gene was low in both patient cohorts in comparison to the healthy controls. Conclusion: Results obtained from this study indicate that DMBT1 protein has the potential to qualify as a specific salivary biomarker as identified in RA and SS patients. DMBT1 protein can therefore be explored further as a noninvasive tool for diagnosis and prognosis.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=1;spage=68;epage=73;aulast=Choudhurydeleted in malignant brain tumor 1methylationprotein expressionrheumatoid arthritissjögren's syndrome |
| spellingShingle | Khushboo Choudhury Monika Gandhi Uma Kumar Sayan Chatterjee Ram Singh Purty Evaluation of the deleted in malignant brain tumor 1 protein expression and DNA methylation profile in rheumatoid arthritis patients Indian Journal of Rheumatology deleted in malignant brain tumor 1 methylation protein expression rheumatoid arthritis sjögren's syndrome |
| title | Evaluation of the deleted in malignant brain tumor 1 protein expression and DNA methylation profile in rheumatoid arthritis patients |
| title_full | Evaluation of the deleted in malignant brain tumor 1 protein expression and DNA methylation profile in rheumatoid arthritis patients |
| title_fullStr | Evaluation of the deleted in malignant brain tumor 1 protein expression and DNA methylation profile in rheumatoid arthritis patients |
| title_full_unstemmed | Evaluation of the deleted in malignant brain tumor 1 protein expression and DNA methylation profile in rheumatoid arthritis patients |
| title_short | Evaluation of the deleted in malignant brain tumor 1 protein expression and DNA methylation profile in rheumatoid arthritis patients |
| title_sort | evaluation of the deleted in malignant brain tumor 1 protein expression and dna methylation profile in rheumatoid arthritis patients |
| topic | deleted in malignant brain tumor 1 methylation protein expression rheumatoid arthritis sjögren's syndrome |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=1;spage=68;epage=73;aulast=Choudhury |
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