Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction
Multible organ failure (MOF) induced by mesenteric infarction is associated with a high mortality rate. This study reports eicosanoid and cytokine levels in the blood of three atherosclerotic patients who ultimately died from MOF induced by mesenteric infarction. High plasma levels of 6- keto-prosta...
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1080/09629359791983 |
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| author | N. Nathan Y. Denizot P. Feiss |
| author_facet | N. Nathan Y. Denizot P. Feiss |
| author_sort | N. Nathan |
| collection | DOAJ |
| description | Multible organ failure (MOF) induced by mesenteric infarction is associated with a high mortality rate. This study reports eicosanoid and cytokine levels in the blood of three atherosclerotic patients who ultimately died from MOF induced by mesenteric infarction. High plasma levels of 6- keto-prostaglandin (PG) F1α (the stable metabolite of
PGI2), interleukin (IL)-6 and IL-8 are observed whereas plasma tumour necrosis factor alpha (TNFα),
TxB2 (the stable metabolite of TxA2), PGE2, leukotrienes (LT)B4 and LTC4, and whole blood platelet-activating factor levels are not different from values obtained in similarly severe atherosclerotic patients. This short report questioned the clinical involvement of TNFα during such a pathology where a persistent translocation of endotoxin has been observed through the gut endothelial barrier. Activation of phospholipase A2 is suggested by the increase in the stable metabolite of PGI2 and might be by itself or through lipidic metabolites, a major systemic stimulus of IL-6 and IL-8 production. |
| format | Article |
| id | doaj-art-2306b8795d614cc484fb24e2ef8e0722 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2306b8795d614cc484fb24e2ef8e07222025-02-03T05:54:14ZengWileyMediators of Inflammation0962-93511466-18611997-01-0161757710.1080/09629359791983Eicosanoid and cytokine levels in plasma of patients during mesenteric infarctionN. Nathan0Y. Denizot1P. Feiss2Department of Anaesthesia, CHU Dupuytren, 2 Avenue Martin Luther King, Limoges 87042, FranceLaboratoire d'Hématologie Expérimentale, Faculté de Médecine, 2 Rue du Dr Marcland, Limoges Cédex 87025, FranceDepartment of Anaesthesia, CHU Dupuytren, 2 Avenue Martin Luther King, Limoges 87042, FranceMultible organ failure (MOF) induced by mesenteric infarction is associated with a high mortality rate. This study reports eicosanoid and cytokine levels in the blood of three atherosclerotic patients who ultimately died from MOF induced by mesenteric infarction. High plasma levels of 6- keto-prostaglandin (PG) F1α (the stable metabolite of PGI2), interleukin (IL)-6 and IL-8 are observed whereas plasma tumour necrosis factor alpha (TNFα), TxB2 (the stable metabolite of TxA2), PGE2, leukotrienes (LT)B4 and LTC4, and whole blood platelet-activating factor levels are not different from values obtained in similarly severe atherosclerotic patients. This short report questioned the clinical involvement of TNFα during such a pathology where a persistent translocation of endotoxin has been observed through the gut endothelial barrier. Activation of phospholipase A2 is suggested by the increase in the stable metabolite of PGI2 and might be by itself or through lipidic metabolites, a major systemic stimulus of IL-6 and IL-8 production.http://dx.doi.org/10.1080/09629359791983 |
| spellingShingle | N. Nathan Y. Denizot P. Feiss Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction Mediators of Inflammation |
| title | Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction |
| title_full | Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction |
| title_fullStr | Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction |
| title_full_unstemmed | Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction |
| title_short | Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction |
| title_sort | eicosanoid and cytokine levels in plasma of patients during mesenteric infarction |
| url | http://dx.doi.org/10.1080/09629359791983 |
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