The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.
The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure. Inactivation of Foxl2 in mice demonstrated its indispensability for female gona...
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Public Library of Science (PLoS)
2010-03-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009477&type=printable |
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| author | Mara Marongiu Manila Deiana Alessandra Meloni Loredana Marcia Alessandro Puddu Antonio Cao David Schlessinger Laura Crisponi |
| author_facet | Mara Marongiu Manila Deiana Alessandra Meloni Loredana Marcia Alessandro Puddu Antonio Cao David Schlessinger Laura Crisponi |
| author_sort | Mara Marongiu |
| collection | DOAJ |
| description | The FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure. Inactivation of Foxl2 in mice demonstrated its indispensability for female gonadal sex determination and ovary development and revealed its antagonism of Sox9, the effector of male testis development. To help to define the regulatory activities of FOXL2, we looked for interacting proteins. Based on yeast two-hybrid screening, we found that FOXL2 interacts with PIAS1 and UBC9, both parts of the sumoylation machinery. We showed that human FOXL2 is sumoylated in transfected cell lines, and that endogenous mouse Foxl2 is comparably sumoylated. This modification changes its cellular localization, stability and transcriptional activity. It is intriguing that similar sumoylation and regulatory consequences have also been reported for SOX9, the male counterpart of FOXL2 in somatic gonadal tissues. |
| format | Article |
| id | doaj-art-22fe7f94ce1e4c5a803578b0c2273ccf |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2010-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-22fe7f94ce1e4c5a803578b0c2273ccf2025-08-20T03:07:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-03-0153e947710.1371/journal.pone.0009477The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity.Mara MarongiuManila DeianaAlessandra MeloniLoredana MarciaAlessandro PudduAntonio CaoDavid SchlessingerLaura CrisponiThe FOXL2 forkhead transcription factor is expressed in ovarian granulosa cells, and mutated FOXL2 causes the blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) and predisposes to premature ovarian failure. Inactivation of Foxl2 in mice demonstrated its indispensability for female gonadal sex determination and ovary development and revealed its antagonism of Sox9, the effector of male testis development. To help to define the regulatory activities of FOXL2, we looked for interacting proteins. Based on yeast two-hybrid screening, we found that FOXL2 interacts with PIAS1 and UBC9, both parts of the sumoylation machinery. We showed that human FOXL2 is sumoylated in transfected cell lines, and that endogenous mouse Foxl2 is comparably sumoylated. This modification changes its cellular localization, stability and transcriptional activity. It is intriguing that similar sumoylation and regulatory consequences have also been reported for SOX9, the male counterpart of FOXL2 in somatic gonadal tissues.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009477&type=printable |
| spellingShingle | Mara Marongiu Manila Deiana Alessandra Meloni Loredana Marcia Alessandro Puddu Antonio Cao David Schlessinger Laura Crisponi The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. PLoS ONE |
| title | The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. |
| title_full | The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. |
| title_fullStr | The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. |
| title_full_unstemmed | The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. |
| title_short | The forkhead transcription factor Foxl2 is sumoylated in both human and mouse: sumoylation affects its stability, localization, and activity. |
| title_sort | forkhead transcription factor foxl2 is sumoylated in both human and mouse sumoylation affects its stability localization and activity |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0009477&type=printable |
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