Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives
A convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a–j was reported. The compounds were confirmed by physical and analytical data and screened for in vitro antioxidant activity by DPPH method, reducing power assay and total antioxidant capacity method. The cytotoxic...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/165258 |
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| author | R. Kalirajan M. H. Mohammed Rafick S. Sankar S. Jubie |
| author_facet | R. Kalirajan M. H. Mohammed Rafick S. Sankar S. Jubie |
| author_sort | R. Kalirajan |
| collection | DOAJ |
| description | A convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a–j was reported. The compounds were confirmed by physical and analytical data and screened for in vitro antioxidant activity by DPPH method, reducing power assay and total antioxidant capacity method. The cytotoxic activity of the compounds was also studied in HEp-2 cell line. The docking studies of the synthesized compounds were performed towards the key nucleoside dsDNA by using AutoDock vina 4.0 programme. All the isoxazole-substituted compounds have significant activities. |
| format | Article |
| id | doaj-art-22e4bbaaa74d4771a7a9ee882cfb36f6 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-22e4bbaaa74d4771a7a9ee882cfb36f62025-02-03T06:08:02ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/165258165258Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine DerivativesR. Kalirajan0M. H. Mohammed Rafick1S. Sankar2S. Jubie3Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University, Tamilnadu Ootacamund 643001, IndiaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University, Tamilnadu Ootacamund 643001, IndiaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University, Tamilnadu Ootacamund 643001, IndiaDepartment of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University, Tamilnadu Ootacamund 643001, IndiaA convenient synthesis of novel isoxazole-substituted 9-anilinoacridine derivatives 5a–j was reported. The compounds were confirmed by physical and analytical data and screened for in vitro antioxidant activity by DPPH method, reducing power assay and total antioxidant capacity method. The cytotoxic activity of the compounds was also studied in HEp-2 cell line. The docking studies of the synthesized compounds were performed towards the key nucleoside dsDNA by using AutoDock vina 4.0 programme. All the isoxazole-substituted compounds have significant activities.http://dx.doi.org/10.1100/2012/165258 |
| spellingShingle | R. Kalirajan M. H. Mohammed Rafick S. Sankar S. Jubie Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives The Scientific World Journal |
| title | Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives |
| title_full | Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives |
| title_fullStr | Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives |
| title_full_unstemmed | Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives |
| title_short | Docking Studies, Synthesis, Characterization and Evaluation of Their Antioxidant and Cytotoxic Activities of Some Novel Isoxazole-Substituted 9-Anilinoacridine Derivatives |
| title_sort | docking studies synthesis characterization and evaluation of their antioxidant and cytotoxic activities of some novel isoxazole substituted 9 anilinoacridine derivatives |
| url | http://dx.doi.org/10.1100/2012/165258 |
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