Roles of Copper Transport Systems Members in Breast Cancer
ABSTRACT Background The occurrence and progression of breast cancer are closely linked to copper ion homeostasis. Both copper deficiency and excess can inhibit breast cancer growth, while copper transport systems may contribute to its progression by regulating copper ion transport and the activity o...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70498 |
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| _version_ | 1832593668321574912 |
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| author | Yichang Chen Chen Li Mengxin Li Bing Han |
| author_facet | Yichang Chen Chen Li Mengxin Li Bing Han |
| author_sort | Yichang Chen |
| collection | DOAJ |
| description | ABSTRACT Background The occurrence and progression of breast cancer are closely linked to copper ion homeostasis. Both copper deficiency and excess can inhibit breast cancer growth, while copper transport systems may contribute to its progression by regulating copper ion transport and the activity of associated proteins. However, a comprehensive review of the roles and applications of copper transport systems in breast cancer remains limited. In this study, we summarize the workflow of copper transport systems and the dual role of copper in cancer, highlighting the contributions of specific members of the copper transport system to breast cancer. Methods A comprehensive search of the PubMed database was conducted to identify articles published over the past 30 years that focus on the relationship between copper transport system members and breast cancer. The findings were synthesized to elucidate the roles and mechanisms of these transporters in the onset and progression of breast cancer. Results We identified 13 members of the copper transport system associated with the occurrence, progression, and mortality of breast cancer, including SLC31A1, DMT1, ATP7A, ATP7B, MTs, GSH, ATOX1, CCS, COX17, SCO1, SCO2, and COX11. Our findings revealed that, apart from STEAP, the remaining 12 members were overexpressed in breast cancer. These members influence the onset, progression, and cell death of breast cancer by modulating biological pathways such as intracellular copper ion levels and ROS. Notably, we observed for the first time that depletion of the copper storage protein GSH leads to increased copper ion accumulation, resulting in cuproptosis in breast cancer cells. Conclusion By integrating the members of the copper transport system in breast cancer, we offer novel insights for the treatment of breast cancer and copper‐related therapies. |
| format | Article |
| id | doaj-art-22dbe8516e33455cba6bdce79f4b60fd |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-22dbe8516e33455cba6bdce79f4b60fd2025-01-20T10:51:32ZengWileyCancer Medicine2045-76342024-12-011324n/an/a10.1002/cam4.70498Roles of Copper Transport Systems Members in Breast CancerYichang Chen0Chen Li1Mengxin Li2Bing Han3Department of Breast Surgery, General Surgery Center First Hospital of Jilin University Changchun ChinaDepartment of Neurosurgery First Hospital of Jilin University Changchun ChinaDepartment of Breast Surgery, General Surgery Center First Hospital of Jilin University Changchun ChinaDepartment of Breast Surgery, General Surgery Center First Hospital of Jilin University Changchun ChinaABSTRACT Background The occurrence and progression of breast cancer are closely linked to copper ion homeostasis. Both copper deficiency and excess can inhibit breast cancer growth, while copper transport systems may contribute to its progression by regulating copper ion transport and the activity of associated proteins. However, a comprehensive review of the roles and applications of copper transport systems in breast cancer remains limited. In this study, we summarize the workflow of copper transport systems and the dual role of copper in cancer, highlighting the contributions of specific members of the copper transport system to breast cancer. Methods A comprehensive search of the PubMed database was conducted to identify articles published over the past 30 years that focus on the relationship between copper transport system members and breast cancer. The findings were synthesized to elucidate the roles and mechanisms of these transporters in the onset and progression of breast cancer. Results We identified 13 members of the copper transport system associated with the occurrence, progression, and mortality of breast cancer, including SLC31A1, DMT1, ATP7A, ATP7B, MTs, GSH, ATOX1, CCS, COX17, SCO1, SCO2, and COX11. Our findings revealed that, apart from STEAP, the remaining 12 members were overexpressed in breast cancer. These members influence the onset, progression, and cell death of breast cancer by modulating biological pathways such as intracellular copper ion levels and ROS. Notably, we observed for the first time that depletion of the copper storage protein GSH leads to increased copper ion accumulation, resulting in cuproptosis in breast cancer cells. Conclusion By integrating the members of the copper transport system in breast cancer, we offer novel insights for the treatment of breast cancer and copper‐related therapies.https://doi.org/10.1002/cam4.70498ATP7A and ATP7Bbreast cancercoppercopper transport systemsSLC31A1 |
| spellingShingle | Yichang Chen Chen Li Mengxin Li Bing Han Roles of Copper Transport Systems Members in Breast Cancer Cancer Medicine ATP7A and ATP7B breast cancer copper copper transport systems SLC31A1 |
| title | Roles of Copper Transport Systems Members in Breast Cancer |
| title_full | Roles of Copper Transport Systems Members in Breast Cancer |
| title_fullStr | Roles of Copper Transport Systems Members in Breast Cancer |
| title_full_unstemmed | Roles of Copper Transport Systems Members in Breast Cancer |
| title_short | Roles of Copper Transport Systems Members in Breast Cancer |
| title_sort | roles of copper transport systems members in breast cancer |
| topic | ATP7A and ATP7B breast cancer copper copper transport systems SLC31A1 |
| url | https://doi.org/10.1002/cam4.70498 |
| work_keys_str_mv | AT yichangchen rolesofcoppertransportsystemsmembersinbreastcancer AT chenli rolesofcoppertransportsystemsmembersinbreastcancer AT mengxinli rolesofcoppertransportsystemsmembersinbreastcancer AT binghan rolesofcoppertransportsystemsmembersinbreastcancer |