PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate
PPARγ and PPARδ agonists represent unique classes of drugs that act through their ability to modulate gene transcription associated with intermediary metabolism, differentiation, tumor suppression, and in some instances proliferation and cell adhesion. PPARγ agonists are used by millions of people e...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/247379 |
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| _version_ | 1832554270403067904 |
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| author | Robert I. Glazer Hongyan Yuan Zhihui Xie Yuzhi Yin |
| author_facet | Robert I. Glazer Hongyan Yuan Zhihui Xie Yuzhi Yin |
| author_sort | Robert I. Glazer |
| collection | DOAJ |
| description | PPARγ and PPARδ agonists represent unique classes of drugs that act through their ability to modulate gene transcription associated with intermediary metabolism, differentiation, tumor suppression, and in some instances proliferation and cell adhesion. PPARγ agonists are used by millions of people each year to treat type 2 diabetes but may also find additional utility as relatively nontoxic potentiators of chemotherapy. PPARδ agonists produce complex actions as shown by their tumor promoting effects in rodents and their cholesterol-lowering action in dyslipidemias. There is now emerging evidence that PPARs regulate tumor suppressor genes and developmental pathways associated with transformation and cell fate determination. This review discusses the role of PPARγ and PPARδ agonists as modulators of these processes. |
| format | Article |
| id | doaj-art-22d2f0e1b4dc4d6293c554740b998de6 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-22d2f0e1b4dc4d6293c554740b998de62025-02-03T05:51:54ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/247379247379PPARγ and PPARδ as Modulators of Neoplasia and Cell FateRobert I. Glazer0Hongyan Yuan1Zhihui Xie2Yuzhi Yin3Department of Oncology and Lombardi Comprehensive Cancer Center, School of Medicine, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USADepartment of Oncology and Lombardi Comprehensive Cancer Center, School of Medicine, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USADepartment of Oncology and Lombardi Comprehensive Cancer Center, School of Medicine, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USADepartment of Oncology and Lombardi Comprehensive Cancer Center, School of Medicine, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USAPPARγ and PPARδ agonists represent unique classes of drugs that act through their ability to modulate gene transcription associated with intermediary metabolism, differentiation, tumor suppression, and in some instances proliferation and cell adhesion. PPARγ agonists are used by millions of people each year to treat type 2 diabetes but may also find additional utility as relatively nontoxic potentiators of chemotherapy. PPARδ agonists produce complex actions as shown by their tumor promoting effects in rodents and their cholesterol-lowering action in dyslipidemias. There is now emerging evidence that PPARs regulate tumor suppressor genes and developmental pathways associated with transformation and cell fate determination. This review discusses the role of PPARγ and PPARδ agonists as modulators of these processes.http://dx.doi.org/10.1155/2008/247379 |
| spellingShingle | Robert I. Glazer Hongyan Yuan Zhihui Xie Yuzhi Yin PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate PPAR Research |
| title | PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate |
| title_full | PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate |
| title_fullStr | PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate |
| title_full_unstemmed | PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate |
| title_short | PPARγ and PPARδ as Modulators of Neoplasia and Cell Fate |
| title_sort | pparγ and pparδ as modulators of neoplasia and cell fate |
| url | http://dx.doi.org/10.1155/2008/247379 |
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