Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons

Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons

Objective: Antagonism of the muscarinic acetylcholine type 1 receptor (M1R) promotes sensory axon repair and is protective in peripheral neuropathy, however, the mechanism remains elusive. We investigated the role of the heat-sensing transient receptor potential melastatin-3 (TRPM3) cation channel i...

Full description

Saved in:

Bibliographic Details
Main Authors:	Sanjana Chauhan, Darrell R. Smith, Shiva Shariati-Ievari, Abhay Srivastava, Sanjiv Dhingra, Michel Aliani, Paul Fernyhough
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Series:	Molecular Metabolism
Subjects:	Axonal regeneration Bioenergetics Diabetic neuropathy GPCR Metabolomics Mitochondria
Online Access:	http://www.sciencedirect.com/science/article/pii/S221287782400214X
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

A unique case report on campylobacter rectus infection leading to acute motor axonal neuropathy in a pediatric patient
by: Uchechukwu Ibewuike, MBBS, et al.
Published: (2025-03-01)

Yersiniosis and acute secondary axonal sensorimotor polyneuropathy: a case report
by: A. Daškevičiūtė, et al.
Published: (2019-03-01)

Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways
by: Lisha Ye, et al.
Published: (2025-03-01)

Automated quantification of axonal and myelin changes in contusion, dislocation, and distraction spinal cord injuries: Insights into targeted remyelination and axonal regeneration
by: Xuan Li, et al.
Published: (2025-02-01)

Axon regeneration: an issue of translation
by: Schaeffer, Julia, et al.
Published: (2024-12-01)

Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice
by: Christian Thome, et al.
Published: (2025-02-01)

Small fiber neuropathy: clinical presentation, diagnostic methods, possibly causes and treatment
by: E. Paulėkas, et al.
Published: (2020-03-01)

GFRα1 Promotes Axon Regeneration after Peripheral Nerve Injury by Functioning as a Ligand
by: Tomoaki Suzuki, et al.
Published: (2025-01-01)

Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition
by: Hannah C. Saternos, et al.
Published: (2025-01-01)

Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity
by: Yang Wang, et al.
Published: (2022-04-01)

Energetic and genomic potential for hydrogenotrophic, formatotrophic, and acetoclastic methanogenesis in surface-expressed serpentinized fluids of the Samail Ophiolite
by: Alta E. G. Howells, et al.
Published: (2025-01-01)

Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival
by: Monika Komza, et al.
Published: (2025-01-01)

Association of Autoantibodies against M2-Muscarinic Acetylcholine Receptor with Atrial Fibrosis in Atrial Fibrillation Patients
by: Guiling Ma, et al.
Published: (2019-01-01)

The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression
by: Callan L. Attwell, et al.
Published: (2025-02-01)

Conserved pattern-based classification of human odorant receptor multigene family
by: Sang Eun Ryu, et al.
Published: (2024-11-01)

Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients
by: Bridgette M. Cumming, et al.
Published: (2024-11-01)

Corrigendum: Longitudinal mitochondrial bioenergetic signatures of blood monocytes and lymphocytes improve during treatment of drug-susceptible pulmonary tuberculosis patients
by: Bridgette M. Cumming, et al.
Published: (2025-01-01)

Interactive effects of temperature, cadmium, and hypoxia on rainbow trout (Oncorhynchus mykiss) liver mitochondrial bioenergetics
by: John O. Onukwufor, et al.
Published: (2025-01-01)

Precision Psychobiotics for Gut–Brain Axis Health: Advancing the Discovery Pipelines to Deliver Mechanistic Pathways and Proven Health Efficacy
by: Rebecca F. Slykerman, et al.
Published: (2025-01-01)

Differences in utilisation of digestible macronutrients between two different size classes of rainbow trout (Oncorhynchus mykiss)
by: Ruben Groot, et al.
Published: (2025-03-01)

Exploring the Antidiarrheal Properties of Papaya Leaf: Insights In Vivo Study in Mice-Model and In Silico Analysis at M3 Muscarinic Acetylcholine Receptor Interaction
by: Nyi Mekar Saptarini, et al.
Published: (2024-01-01)

The role of neurofilament light chain in the context of neurological disorders
by: V. Taluntienė, et al.
Published: (2020-12-01)

AiGPro: a multi-tasks model for profiling of GPCRs for agonist and antagonist
by: Rahul Brahma, et al.
Published: (2025-01-01)

Phosphorylation of Bok at Ser-8 blocks its ability to suppress IP3R-mediated calcium mobilization
by: Caden G. Bonzerato, et al.
Published: (2025-01-01)

MOF-derived intelligent arenobufagin nanocomposites with glucose metabolism inhibition for enhanced bioenergetic therapy and integrated photothermal-chemodynamic-chemotherapy
by: Lihua Chen, et al.
Published: (2025-01-01)

Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice
by: Kimberley A. Stephenson, et al.
Published: (2025-02-01)

Adalimumab-induced optic neuropathy in a patient with Behçet’s syndrome
by: Sofia Miranda, et al.
Published: (2025-01-01)

AGS3-based optogenetic GDI induces GPCR-independent Gβγ signalling and macrophage migration
by: Waruna Thotamune, et al.
Published: (2025-02-01)

Hereditary neuropathy with liability to pressure palsies: a case series report
by: S. Naudžiūnaitė, et al.
Published: (2020-12-01)

Ankle reflex and neurological symptom score: a primary level screening method for diabetic peripheral neuropathy
by: Xueya Ma, et al.
Published: (2024-02-01)

Endothelial protease-activated receptor 4: impotent or important?
by: Rahul Rajala, et al.
Published: (2025-01-01)

Regarding Treatment of Painful Diabetic Neuropathy With 10 kHz Spinal Cord Stimulation: Long-Term Improvements in Hemoglobin A1c, Weight, and Sleep Accompany Pain Relief for People With Type 2 Diabetes [Letter]
by: Zhou PB, et al.
Published: (2025-01-01)

Unveiling Silent Atherosclerosis in Type 1 Diabetes: The Role of Glycoprotein and Lipoprotein Lipidomics, and Cardiac Autonomic Neuropathy
by: Sara de Lope Quiñones, et al.
Published: (2025-01-01)

Correlation between traumatic brain injury, obesity and insulin-resistance – a case report
by: Laura De Wilde, et al.
Published: (2025-02-01)

Post-injury treatment with 7,8-dihydroxyflavone attenuates white matter pathology in aged mice following focal traumatic brain injury
by: Georgios Michalettos, et al.
Published: (2025-01-01)

Enlarged Iliopsoas Bursa Compressing the Femoral Nerve Resulting in Femoral Mononeuropathy and Denervation Edema
by: Kapil Shirodkar, et al.

Deterioration in ankle reflex is associated with a reduced estimated glomerular filtration rate in patients with type 2 diabetes: A retrospective observational cohort study
by: Taichi Muramatsu, et al.
Published: (2025-02-01)

TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets
by: Nelson S. Yee, et al.
Published: (2012-01-01)

GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism
by: Tian Qiu, et al.
Published: (2025-02-01)

Climate-smart livestock nutrition in semi-arid Southern African agricultural systems
by: Felix Fushai, et al.
Published: (2025-02-01)