Insights into the Roles of B Cells in Patients with Sepsis
Sepsis is a life-threatening yet common disease, still posing high mortality worldwide. Sepsis-related deaths primarily occur during immunosuppression; the disease can hamper the numbers and function of B cells, which mediate innate and adaptive immune responses to maintain immune homeostasis. Dysfu...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2023/7408967 |
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| _version_ | 1832559263284723712 |
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| author | Xijie Dong Hao Tu Shuang Qin Xiangjun Bai Fan Yang Zhanfei Li |
| author_facet | Xijie Dong Hao Tu Shuang Qin Xiangjun Bai Fan Yang Zhanfei Li |
| author_sort | Xijie Dong |
| collection | DOAJ |
| description | Sepsis is a life-threatening yet common disease, still posing high mortality worldwide. Sepsis-related deaths primarily occur during immunosuppression; the disease can hamper the numbers and function of B cells, which mediate innate and adaptive immune responses to maintain immune homeostasis. Dysfunction of B cells, along with aggravated immunosuppression, are closely related to poor prognosis. However, B cells in patients with sepsis have garnered little attention. This article focuses on the significance of B-cell subsets, including regulatory B cells, in sepsis and how the counts and function of circulating B cells are affected in patients with sepsis. Finally, potential B-cell-related immunotherapies for sepsis are explored. |
| format | Article |
| id | doaj-art-22d19a4328034ddfbde94218fccbe29b |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-22d19a4328034ddfbde94218fccbe29b2025-02-03T01:30:24ZengWileyJournal of Immunology Research2314-71562023-01-01202310.1155/2023/7408967Insights into the Roles of B Cells in Patients with SepsisXijie Dong0Hao Tu1Shuang Qin2Xiangjun Bai3Fan Yang4Zhanfei Li5Trauma Center/Department of Emergency and Traumatic SurgeryTrauma Center/Department of Emergency and Traumatic SurgeryDepartment of Radiation OncologyTrauma Center/Department of Emergency and Traumatic SurgeryTrauma Center/Department of Emergency and Traumatic SurgeryTrauma Center/Department of Emergency and Traumatic SurgerySepsis is a life-threatening yet common disease, still posing high mortality worldwide. Sepsis-related deaths primarily occur during immunosuppression; the disease can hamper the numbers and function of B cells, which mediate innate and adaptive immune responses to maintain immune homeostasis. Dysfunction of B cells, along with aggravated immunosuppression, are closely related to poor prognosis. However, B cells in patients with sepsis have garnered little attention. This article focuses on the significance of B-cell subsets, including regulatory B cells, in sepsis and how the counts and function of circulating B cells are affected in patients with sepsis. Finally, potential B-cell-related immunotherapies for sepsis are explored.http://dx.doi.org/10.1155/2023/7408967 |
| spellingShingle | Xijie Dong Hao Tu Shuang Qin Xiangjun Bai Fan Yang Zhanfei Li Insights into the Roles of B Cells in Patients with Sepsis Journal of Immunology Research |
| title | Insights into the Roles of B Cells in Patients with Sepsis |
| title_full | Insights into the Roles of B Cells in Patients with Sepsis |
| title_fullStr | Insights into the Roles of B Cells in Patients with Sepsis |
| title_full_unstemmed | Insights into the Roles of B Cells in Patients with Sepsis |
| title_short | Insights into the Roles of B Cells in Patients with Sepsis |
| title_sort | insights into the roles of b cells in patients with sepsis |
| url | http://dx.doi.org/10.1155/2023/7408967 |
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