Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD

Allogeneic DNT cell therapy synergizes with T cells to promote anti-leukemic activities while suppressing GvHD

Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a second-line treatment with curative potential for leukemia patients. However, the prognosis of allo-HSCT patients with disease relapse or graft-versus-host disease (GvHD) is poor. CD4+ or CD8+ conventional T (Tconv) cells a...

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Bibliographic Details
Main Authors: Jongbok Lee, Hyeonjeong Kang, Branson Chen, Yoosu Na, Ismat Khatri, Fraser Soares, Housheng Hansen He, Arjun D. Law, Tianzhong Pan, Armin Gerbitz, Xiaoyu Zhu, Mark D. Minden, Li Zhang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Double negative T cell
Allogeneic hematopoietic stem cell transplantation
Graft-versus-host disease
Graft-versus-leukemia
Donor lymphocyte infusion
Online Access:https://doi.org/10.1186/s13046-024-03247-w
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