Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern China
BackgroundTo compare the risk factors, clinical outcomes, and mortality rates between carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-sensitive Klebsiella pneumoniae (CSKP) infections.MethodsA retrospective cohort study was conducted on patients with Klebsiella pneumoniae infections...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1499057/full |
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| author | Bu Wang Bu Wang Wei Zhang Hongxia Zhang Maochen Li Zhihua Zhang Xiaocui Peng Na Wang Ning Song |
| author_facet | Bu Wang Bu Wang Wei Zhang Hongxia Zhang Maochen Li Zhihua Zhang Xiaocui Peng Na Wang Ning Song |
| author_sort | Bu Wang |
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| description | BackgroundTo compare the risk factors, clinical outcomes, and mortality rates between carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-sensitive Klebsiella pneumoniae (CSKP) infections.MethodsA retrospective cohort study was conducted on patients with Klebsiella pneumoniae infections admitted to a tertiary hospital in Zhangjiakou, China. The research period is from January 2021 to December 2022. Data were analyzed using SPSS 24.0 and R. Univariate analysis identified potential risk factors for CRKP infections using appropriate statistical methods, followed by multivariable logistic regression to determine independent risk factors. Mortality rates between CRKP and CSKP groups were compared using chi-square tests, and survival curves were generated with the Kaplan–Meier method.ResultsThe study included 283 patients, with 104 (36.7%) infected by CRKP and 179 (63.3%) by CSKP. CRKP patients had significantly higher body temperature, white blood cell counts, and inflammatory markers, while showing lower diastolic blood pressure and oxygen saturation (p < 0.05). CRKP infections were predominantly found in the ICU (49%) and mainly isolated from sputum (59%). Independent risk factors for CRKP included elevated C-reactive protein (OR = 1.02) and solid tumors (OR = 18.186). CRKP patients experienced longer hospital stays (25 days vs. 12 days for CSKP), longer ICU stays (13 days vs. 7 days), and higher 30-day mortality (23.1% vs. 17.9%, p = 0.012). The deceased group had elevated procalcitonin and creatinine levels, longer prothrombin time, and a greater need for mechanical ventilation compared to survivors (p < 0.05).ConclusionPatients with CRKP infections had higher mortality rates and longer hospital stays than those with CSKP infections. Previous hospitalization, hospitalization in an ICU, and mechanical ventilation were independent risk factors for CRKP infection. |
| format | Article |
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| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-22b4fa66e1da4cf49d940e25ab84baa82025-02-05T07:33:01ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.14990571499057Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern ChinaBu Wang0Bu Wang1Wei Zhang2Hongxia Zhang3Maochen Li4Zhihua Zhang5Xiaocui Peng6Na Wang7Ning Song8Department of Infectious Diseases, Hebei Medical University, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Hebei North University, Zhangjiakou, Hebei Province, ChinaCentral Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Hebei North University, Zhangjiakou, Hebei Province, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Hebei North University, Zhangjiakou, Hebei Province, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Hebei North University, Zhangjiakou, Hebei Province, ChinaDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Hebei North University, Hebei North University, Zhangjiakou, Hebei Province, ChinaAdministration Department of Nosocomial Infection, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei Province, ChinaDepartment of Infectious Diseases, Hebei Medical University, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, ChinaBackgroundTo compare the risk factors, clinical outcomes, and mortality rates between carbapenem-resistant Klebsiella pneumoniae (CRKP) and carbapenem-sensitive Klebsiella pneumoniae (CSKP) infections.MethodsA retrospective cohort study was conducted on patients with Klebsiella pneumoniae infections admitted to a tertiary hospital in Zhangjiakou, China. The research period is from January 2021 to December 2022. Data were analyzed using SPSS 24.0 and R. Univariate analysis identified potential risk factors for CRKP infections using appropriate statistical methods, followed by multivariable logistic regression to determine independent risk factors. Mortality rates between CRKP and CSKP groups were compared using chi-square tests, and survival curves were generated with the Kaplan–Meier method.ResultsThe study included 283 patients, with 104 (36.7%) infected by CRKP and 179 (63.3%) by CSKP. CRKP patients had significantly higher body temperature, white blood cell counts, and inflammatory markers, while showing lower diastolic blood pressure and oxygen saturation (p < 0.05). CRKP infections were predominantly found in the ICU (49%) and mainly isolated from sputum (59%). Independent risk factors for CRKP included elevated C-reactive protein (OR = 1.02) and solid tumors (OR = 18.186). CRKP patients experienced longer hospital stays (25 days vs. 12 days for CSKP), longer ICU stays (13 days vs. 7 days), and higher 30-day mortality (23.1% vs. 17.9%, p = 0.012). The deceased group had elevated procalcitonin and creatinine levels, longer prothrombin time, and a greater need for mechanical ventilation compared to survivors (p < 0.05).ConclusionPatients with CRKP infections had higher mortality rates and longer hospital stays than those with CSKP infections. Previous hospitalization, hospitalization in an ICU, and mechanical ventilation were independent risk factors for CRKP infection.https://www.frontiersin.org/articles/10.3389/fmed.2025.1499057/fullantibioticdrug resistant bacteria30-day mortalityodds ratioclinical outcomes |
| spellingShingle | Bu Wang Bu Wang Wei Zhang Hongxia Zhang Maochen Li Zhihua Zhang Xiaocui Peng Na Wang Ning Song Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern China Frontiers in Medicine antibiotic drug resistant bacteria 30-day mortality odds ratio clinical outcomes |
| title | Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern China |
| title_full | Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern China |
| title_fullStr | Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern China |
| title_full_unstemmed | Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern China |
| title_short | Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospital in Northern China |
| title_sort | comparative analysis of clinical characteristics and outcomes between carbapenem resistant and carbapenem sensitive klebsiella pneumoniae infections insights from a tertiary hospital in northern china |
| topic | antibiotic drug resistant bacteria 30-day mortality odds ratio clinical outcomes |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1499057/full |
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