Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes
Aims. To assess the association of blood oxygen-transport capacity variables with the prevalence of diabetic retinopathy (DR), retinal ischemia, and macular oedema in patients with type 2 diabetes mellitus (T2DM). Methods. Cross-sectional, case-control study (N=312) with T2DM: 153 individuals with D...
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/3674946 |
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| author | Alicia Traveset Esther Rubinat Emilio Ortega Nuria Alcubierre Beatriz Vazquez Marta Hernández Carmen Jurjo Ramon Espinet Juan Antonio Ezpeleta Didac Mauricio |
| author_facet | Alicia Traveset Esther Rubinat Emilio Ortega Nuria Alcubierre Beatriz Vazquez Marta Hernández Carmen Jurjo Ramon Espinet Juan Antonio Ezpeleta Didac Mauricio |
| author_sort | Alicia Traveset |
| collection | DOAJ |
| description | Aims. To assess the association of blood oxygen-transport capacity variables with the prevalence of diabetic retinopathy (DR), retinal ischemia, and macular oedema in patients with type 2 diabetes mellitus (T2DM). Methods. Cross-sectional, case-control study (N=312) with T2DM: 153 individuals with DR and 159 individuals with no DR. Participants were classified according to the severity of DR and the presence of retinal ischemia or macular oedema. Hematological variables were collected by standardized methods. Three logistic models were adjusted to ascertain the association between hematologic variables with the severity of DR and the presence of retinal ischemia or macular oedema. Results. Individuals with severe DR showed significantly lower hemoglobin, hematocrit, and erythrocyte levels compared with those with mild disease and in individuals with retinal ischemia and macular oedema compared with those without these disorders. Hemoglobin was the only factor that showed a significant inverse association with the severity of DR [beta-coefficient = −0.52, P value = 0.003] and retinal ischemia [beta-coefficient = −0.49, P value = 0.001]. Lower erythrocyte level showed a marginally significant association with macular oedema [beta-coefficient = −0.86, P value = 0.055]. Conclusions. In patients with DR, low blood oxygen-transport capacity was associated with more severe DR and the presence of retinal ischemia. Low hemoglobin levels may have a key role in the development and progression of DR. |
| format | Article |
| id | doaj-art-22aa97d0042548f4b17b6df4089ef86d |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-22aa97d0042548f4b17b6df4089ef86d2025-02-03T01:12:25ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/36749463674946Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 DiabetesAlicia Traveset0Esther Rubinat1Emilio Ortega2Nuria Alcubierre3Beatriz Vazquez4Marta Hernández5Carmen Jurjo6Ramon Espinet7Juan Antonio Ezpeleta8Didac Mauricio9Department of Ophthalmology, University Hospital Arnau de Vilanova, 25198 Lleida, SpainDepartment of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, 25198 Lleida, SpainDepartment of Endocrinology and Nutrition, Institut d’Investigacions Biomediques August Pi Suñer, CIBER de Obesidad y Nutrición, Hospital Clinic, 08036 Barcelona, SpainInstitut de Recerca Biomedica de Lleida, University of Lleida, 25198 Lleida, SpainDepartment of Optometry, University Hospital Arnau de Vilanova, 25198 Lleida, SpainDepartment of Endocrinology and Nutrition, University Hospital Arnau de Vilanova, 25198 Lleida, SpainDepartment of Ophthalmology, University Hospital Arnau de Vilanova, 25198 Lleida, SpainDepartment of Ophthalmology, University Hospital Arnau de Vilanova, 25198 Lleida, SpainDepartment of Ophthalmology, University Hospital Arnau de Vilanova, 25198 Lleida, SpainDepartment of Endocrinology and Nutrition, CIBER of Diabetes and Associated Metabolic Diseases (CIBERDEM), Health Sciences Research Institute and University Hospital Germans Trias i Pujol, 08916 Badalona, SpainAims. To assess the association of blood oxygen-transport capacity variables with the prevalence of diabetic retinopathy (DR), retinal ischemia, and macular oedema in patients with type 2 diabetes mellitus (T2DM). Methods. Cross-sectional, case-control study (N=312) with T2DM: 153 individuals with DR and 159 individuals with no DR. Participants were classified according to the severity of DR and the presence of retinal ischemia or macular oedema. Hematological variables were collected by standardized methods. Three logistic models were adjusted to ascertain the association between hematologic variables with the severity of DR and the presence of retinal ischemia or macular oedema. Results. Individuals with severe DR showed significantly lower hemoglobin, hematocrit, and erythrocyte levels compared with those with mild disease and in individuals with retinal ischemia and macular oedema compared with those without these disorders. Hemoglobin was the only factor that showed a significant inverse association with the severity of DR [beta-coefficient = −0.52, P value = 0.003] and retinal ischemia [beta-coefficient = −0.49, P value = 0.001]. Lower erythrocyte level showed a marginally significant association with macular oedema [beta-coefficient = −0.86, P value = 0.055]. Conclusions. In patients with DR, low blood oxygen-transport capacity was associated with more severe DR and the presence of retinal ischemia. Low hemoglobin levels may have a key role in the development and progression of DR.http://dx.doi.org/10.1155/2016/3674946 |
| spellingShingle | Alicia Traveset Esther Rubinat Emilio Ortega Nuria Alcubierre Beatriz Vazquez Marta Hernández Carmen Jurjo Ramon Espinet Juan Antonio Ezpeleta Didac Mauricio Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes Journal of Diabetes Research |
| title | Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes |
| title_full | Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes |
| title_fullStr | Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes |
| title_full_unstemmed | Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes |
| title_short | Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes |
| title_sort | lower hemoglobin concentration is associated with retinal ischemia and the severity of diabetic retinopathy in type 2 diabetes |
| url | http://dx.doi.org/10.1155/2016/3674946 |
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