The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis
The pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized. Molecular signaling pathways are not well described in psoriasis, as well as psoriatic arthritis, which is seen in up to 40% of patients with psoriasis. Signaling...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/569751 |
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| author | Athanasios Mavropoulos Eirini I. Rigopoulou Christos Liaskos Dimitrios P. Bogdanos Lazaros I. Sakkas |
| author_facet | Athanasios Mavropoulos Eirini I. Rigopoulou Christos Liaskos Dimitrios P. Bogdanos Lazaros I. Sakkas |
| author_sort | Athanasios Mavropoulos |
| collection | DOAJ |
| description | The pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized. Molecular signaling pathways are not well described in psoriasis, as well as psoriatic arthritis, which is seen in up to 40% of patients with psoriasis. Signaling pathway defects have long been hypothesized to participate in the pathology of psoriasis, yet their implication in the altered psoriatic gene expression still remains unclear. Emerging data suggest a potential pathogenic role for mitogen activated protein kinases p38 (p38 MAPK) extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK) in the development of psoriasis. The data are still limited, though, for psoriatic arthritis. This review discusses the current data suggesting a crucial role for p38 MAPK in the pathogenesis of these disorders. |
| format | Article |
| id | doaj-art-22a3b3d98316499fa8c9db269c920955 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-22a3b3d98316499fa8c9db269c9209552025-02-03T01:30:52ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/569751569751The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic ArthritisAthanasios Mavropoulos0Eirini I. Rigopoulou1Christos Liaskos2Dimitrios P. Bogdanos3Lazaros I. Sakkas4Cellular Immunotherapy and Molecular Immunodiagnostics, Institute of Research and Technology Thessaly, 41222 Larissa, GreeceDepartment of Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41110 Larissa, GreeceCellular Immunotherapy and Molecular Immunodiagnostics, Institute of Research and Technology Thessaly, 41222 Larissa, GreeceCellular Immunotherapy and Molecular Immunodiagnostics, Institute of Research and Technology Thessaly, 41222 Larissa, GreeceDepartment of Medicine, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, 41110 Larissa, GreeceThe pathogenetic mechanisms responsible for the induction of immune-mediated disorders, such as psoriasis, remain not well characterized. Molecular signaling pathways are not well described in psoriasis, as well as psoriatic arthritis, which is seen in up to 40% of patients with psoriasis. Signaling pathway defects have long been hypothesized to participate in the pathology of psoriasis, yet their implication in the altered psoriatic gene expression still remains unclear. Emerging data suggest a potential pathogenic role for mitogen activated protein kinases p38 (p38 MAPK) extracellular signal-regulated kinase 1/2 (ERK1/2), and c-Jun N-terminal kinase (JNK) in the development of psoriasis. The data are still limited, though, for psoriatic arthritis. This review discusses the current data suggesting a crucial role for p38 MAPK in the pathogenesis of these disorders.http://dx.doi.org/10.1155/2013/569751 |
| spellingShingle | Athanasios Mavropoulos Eirini I. Rigopoulou Christos Liaskos Dimitrios P. Bogdanos Lazaros I. Sakkas The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis Clinical and Developmental Immunology |
| title | The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis |
| title_full | The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis |
| title_fullStr | The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis |
| title_full_unstemmed | The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis |
| title_short | The Role of p38 MAPK in the Aetiopathogenesis of Psoriasis and Psoriatic Arthritis |
| title_sort | role of p38 mapk in the aetiopathogenesis of psoriasis and psoriatic arthritis |
| url | http://dx.doi.org/10.1155/2013/569751 |
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