Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols
Diabetes mellitus is a chronic disease that threatens human health. The disease is caused by a metabolic disorder of the endocrine system, and long-term illness can lead to tissue and organ damage to the cardiovascular, endocrine, nervous, and urinary systems. Currently, the disease prevalence is 11...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/5837804 |
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| _version_ | 1832550262684778496 |
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| author | Qi Ge Liang Chen Keping Chen |
| author_facet | Qi Ge Liang Chen Keping Chen |
| author_sort | Qi Ge |
| collection | DOAJ |
| description | Diabetes mellitus is a chronic disease that threatens human health. The disease is caused by a metabolic disorder of the endocrine system, and long-term illness can lead to tissue and organ damage to the cardiovascular, endocrine, nervous, and urinary systems. Currently, the disease prevalence is 11.4%, the treatment rate is 48.2%, and the mortality rate is 2.7% worldwide. Comprehensive and effective control of diabetes, as well as the use of insulin, requires further study to develop additional treatment options. Here, we reviewed the current reprogramming of somatic cells using specific factors to induced pluripotent stem (iPS) cells capable of repairing islet β cell damage in diabetes patients to treat patients with type 1 diabetes mellitus. We also discuss the shortcomings associated with clinical use of iPS cells. Additionally, certain polyphenols found in spices might improve glucose homeostasis and insulin resistance in diabetes patients, thereby constituting promising options for the treatment of type 2 diabetes. |
| format | Article |
| id | doaj-art-228c397a066e468ca0cc6b0443bb4542 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-228c397a066e468ca0cc6b0443bb45422025-02-03T06:07:10ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/58378045837804Treatment of Diabetes Mellitus Using iPS Cells and Spice PolyphenolsQi Ge0Liang Chen1Keping Chen2Institute of Life Science, Jiangsu University, Zhenjiang, Jiangsu 212013, ChinaInstitute of Life Science, Jiangsu University, Zhenjiang, Jiangsu 212013, ChinaInstitute of Life Science, Jiangsu University, Zhenjiang, Jiangsu 212013, ChinaDiabetes mellitus is a chronic disease that threatens human health. The disease is caused by a metabolic disorder of the endocrine system, and long-term illness can lead to tissue and organ damage to the cardiovascular, endocrine, nervous, and urinary systems. Currently, the disease prevalence is 11.4%, the treatment rate is 48.2%, and the mortality rate is 2.7% worldwide. Comprehensive and effective control of diabetes, as well as the use of insulin, requires further study to develop additional treatment options. Here, we reviewed the current reprogramming of somatic cells using specific factors to induced pluripotent stem (iPS) cells capable of repairing islet β cell damage in diabetes patients to treat patients with type 1 diabetes mellitus. We also discuss the shortcomings associated with clinical use of iPS cells. Additionally, certain polyphenols found in spices might improve glucose homeostasis and insulin resistance in diabetes patients, thereby constituting promising options for the treatment of type 2 diabetes.http://dx.doi.org/10.1155/2017/5837804 |
| spellingShingle | Qi Ge Liang Chen Keping Chen Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols Journal of Diabetes Research |
| title | Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols |
| title_full | Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols |
| title_fullStr | Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols |
| title_full_unstemmed | Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols |
| title_short | Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols |
| title_sort | treatment of diabetes mellitus using ips cells and spice polyphenols |
| url | http://dx.doi.org/10.1155/2017/5837804 |
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