Chagas Disease: Still Many Unsolved Issues
Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/912965 |
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| author | José M. Álvarez Raissa Fonseca Henrique Borges da Silva Cláudio R. F. Marinho Karina R. Bortoluci Luiz R. Sardinha Sabrina Epiphanio Maria Regina D'Império Lima |
| author_facet | José M. Álvarez Raissa Fonseca Henrique Borges da Silva Cláudio R. F. Marinho Karina R. Bortoluci Luiz R. Sardinha Sabrina Epiphanio Maria Regina D'Império Lima |
| author_sort | José M. Álvarez |
| collection | DOAJ |
| description | Over the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease remain unanswered: “Why does the host immune system fail to provide sterile immunity?” and “Why do only a proportion of infected individuals develop chronic pathology?” In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular T. cruzi contributes to parasite persistence in the heart and the development of chronic pathology. |
| format | Article |
| id | doaj-art-2283587ddd9840ada99348d7f2178adc |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2283587ddd9840ada99348d7f2178adc2025-02-03T05:46:21ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/912965912965Chagas Disease: Still Many Unsolved IssuesJosé M. Álvarez0Raissa Fonseca1Henrique Borges da Silva2Cláudio R. F. Marinho3Karina R. Bortoluci4Luiz R. Sardinha5Sabrina Epiphanio6Maria Regina D'Império Lima7Department of Immunology, Biomedical Sciences Institute, University of São Paulo, 05508-000 São Paulo, SP, BrazilDepartment of Immunology, Biomedical Sciences Institute, University of São Paulo, 05508-000 São Paulo, SP, BrazilDepartment of Immunology, Biomedical Sciences Institute, University of São Paulo, 05508-000 São Paulo, SP, BrazilDepartment of Parasitology, Biomedical Sciences Institute, University of São Paulo, 05508-000 São Paulo, SP, BrazilDepartment of Biological Sciences, UNIFESP (Campus Diadema), 09972-270 Diadema, SP, BrazilHospital Israelita Albert Einstein, 05652-000 São Paulo, SP, BrazilDepartment of Clinical and Toxicological Analyses, Faculty of Pharmaceutical Sciences, University of São Paulo, 05508-000 São Paulo, SP, BrazilDepartment of Immunology, Biomedical Sciences Institute, University of São Paulo, 05508-000 São Paulo, SP, BrazilOver the past 20 years, the immune effector mechanisms involved in the control of Trypanosoma cruzi, as well as the receptors participating in parasite recognition by cells of the innate immune system, have been largely described. However, the main questions on the physiopathology of Chagas disease remain unanswered: “Why does the host immune system fail to provide sterile immunity?” and “Why do only a proportion of infected individuals develop chronic pathology?” In this review, we describe the mechanisms proposed to explain the inability of the immune system to eradicate the parasite and the elements that allow the development of chronic heart disease. Moreover, we discuss the possibility that the inability of infected cardiomyocytes to sense intracellular T. cruzi contributes to parasite persistence in the heart and the development of chronic pathology.http://dx.doi.org/10.1155/2014/912965 |
| spellingShingle | José M. Álvarez Raissa Fonseca Henrique Borges da Silva Cláudio R. F. Marinho Karina R. Bortoluci Luiz R. Sardinha Sabrina Epiphanio Maria Regina D'Império Lima Chagas Disease: Still Many Unsolved Issues Mediators of Inflammation |
| title | Chagas Disease: Still Many Unsolved Issues |
| title_full | Chagas Disease: Still Many Unsolved Issues |
| title_fullStr | Chagas Disease: Still Many Unsolved Issues |
| title_full_unstemmed | Chagas Disease: Still Many Unsolved Issues |
| title_short | Chagas Disease: Still Many Unsolved Issues |
| title_sort | chagas disease still many unsolved issues |
| url | http://dx.doi.org/10.1155/2014/912965 |
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